| 1558200 | Ang | angiogenin, ribonuclease, RNase A family, 5 | This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009] | 14 | 51328607 | 51339462 | Mouse | 350 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1594539 | Ang | angiogenin | ENCODES a protein that exhibits actin binding (ortholog); copper ion binding (ortholog); heparin binding (ortholog); INVOLVED IN liver development; angiogenesis (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); ASSOCIATED WITH Reperfusion Injury; transie nt cerebral ischemia; Acute-Phase Reaction (ortholog); FOUND IN angiogenin-PRI complex (ortholog); basement membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether | 15 | 26786233 | 26796883 | Rat | 286 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14013658 | ANG | angiogenin | ENCODES a protein that exhibits protein homodimerization activity (ortholog); tRNA-specific ribonuclease activity (ortholog); INVOLVED IN angiogenesis (ortholog); hematopoietic stem cell proliferation (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Acute-Phase Reacti on (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endocytic vesicle (ortholog); extracellular space (ortholog) | | | | Pig | 110 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733136 | ANGPT1 | angiopoietin 1 | This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020] | 8 | 107249482 | 107497918 | Human | 306 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1551549 | Angpt1 | angiopoietin 1 | This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated musc les by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] | 15 | 42288063 | 42540373 | Mouse | 370 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12138683 | ANGPT1 | angiopoietin 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); angiogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN angiopoietin signaling pathway; ASSOCIATED WITH alcohol d ependence (ortholog); brain ischemia (ortholog); diabetic retinopathy (ortholog); FOUND IN extracellular space (ortholog) | 13 | 8068920 | 8312090 | Dog | 114 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322541 | TM7SF2 | transmembrane 7 superfamily member 2 | Enables Delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2025] | 11 | 65111872 | 65116230 | Human | 233 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1322542 | Tm7sf2 | transmembrane 7 superfamily member 2 | Enables Delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in organelle membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; liver; and nervous system. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6112851 | 6117880 | Mouse | 250 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
