Enables alkaline phosphatase activity. Located in myofibril. Is expressed in early conceptus; intestine; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related
ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); ASSOCIATED WITH Spontaneous Abortions (ortholog); FOUND IN plasma membrane (inferred); side of membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; 1,2-dimethylhydrazine (ortholog)