| 2088 | Aldh3a1 | aldehyde dehydrogenase 3 family, member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity (ortholog); aldehyde dehydrogenase (NAD+) activity (ortholog); INVOLVED IN positive regulation of cell population proliferation; response to cAMP; response to glucocorticoid; PARTICI PATES IN alkaptonuria pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN cytosol; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 1,2,3,7,8-Pentachlorodibenzodioxin; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether | 10 | 46392464 | 46402151 | Rat | 333 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733180 | ALDH3A1 | aldehyde dehydrogenase 3 family member A1 | Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplas mic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] | 17 | 19737984 | 19748298 | Human | 335 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733181 | Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm and membrane. Is expressed in several structures, inc luding alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 61099336 | 61109244 | Mouse | 351 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9022544 | Aldh3a1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); alcohol dehydrogenase (NADP+) activity (ortholog); aldehyde dehydrogenase (NAD+) activity (ortholog); INVOLVED IN aldehyde metabolic process (ortholog); positive regulation of cell population proliferation (ort holog); response to cAMP (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | NW_004955467 | 96140 | 105738 | Chinchilla | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11913304 | ALDH3A1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacody namics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN membrane (ortholog) | 17 | 31384740 | 31395719 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12363428 | ALDH3A1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacody namics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN membrane (ortholog) | 5 | 40466237 | 40474272 | Dog | 50 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12682434 | Aldh3a1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacody namics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred) | NW_004936881 | 71047 | 77543 | Squirrel | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14133228 | ALDH3A1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacody namics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH zearalenone | | | | Pig | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18768304 | ALDH3A1 | aldehyde dehydrogenase 3 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacody namics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); cataract (ortholog); FOUND IN membrane (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914370 | LOC101699453 | aldehyde dehydrogenase, dimeric NADP-preferring | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (inferred); aldehyde dehydrogenase (NAD+) activity (inferred); aldehyde dehydrogenase [NAD(P)+] activity (inferred); INVOLVED IN aldehyde metabolic process (inferred); lipid metabolic process (inferred); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 12 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16563970 | AC005722.4 | novel transcript, antisense to ALDH3A1 | | | | | Human | | name | gene, lncrna |