Aldh3a1 (aldehyde dehydrogenase 3 family member A1)

Gene: Aldh3a1 (aldehyde dehydrogenase 3 family member A1) Ictidomys tridecemlineatus

Analyze

Symbol:

Aldh3a1

Name:

aldehyde dehydrogenase 3 family member A1

RGD ID:

12682434

Description:

ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); response to cAMP (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; ASSOCIATED WITH arteriosclerosis (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aldehyde dehydrogenase 3 family, member A1; aldehyde dehydrogenase, dimeric NADP-preferring; LOC101970529

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	60,509,720 - 60,516,217 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936881	70,951 - 77,839 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936881	71,047 - 77,543 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arteriosclerosis (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

cataract (ISO)

Corneal Injuries (ISO)

genetic disease (ISO)

keratoconus (ISO)

Meckel Syndrome 9 (ISO)

Potocki-Lupski syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular aldehyde metabolic process (IEA)

positive regulation of cell population proliferation (ISO)

response to cAMP (ISO)

response to glucocorticoid (ISO)

response to hypoxia (ISO)

response to nutrient (ISO)

response to organic cyclic compound (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

endoplasmic reticulum (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

3-chloroallyl aldehyde dehydrogenase activity (IEA,ISO)

alcohol dehydrogenase (NADP+) activity (IEA)

aldehyde dehydrogenase (NAD+) activity (IEA)

benzaldehyde dehydrogenase (NAD+) activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alkaptonuria pathway (ISO)

cyclophosphamide pharmacodynamics pathway (ISO)

cyclophosphamide pharmacokinetics pathway (ISO)

D-glycericacidemia pathway (ISO)

disulfiram pharmacodynamics pathway (ISO)

dopamine beta-hydroxylase deficiency pathway (ISO)

familial lipoprotein lipase deficiency pathway (ISO)

felbamate pharmacokinetics pathway (ISO)

glycerol kinase deficiency pathway (ISO)

glycerolipid metabolic pathway (ISO)

hawkinsinuria pathway (ISO)

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

ifosfamide pharmacodynamics pathway (ISO)

ifosfamide pharmacokinetics pathway (ISO)

tyrosine metabolic pathway (ISO)

tyrosinemia type I pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aldh3a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	60,509,720 - 60,516,217 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936881	70,951 - 77,839 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936881	71,047 - 77,543 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH3A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	19,737,984 - 19,748,298 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	19,737,984 - 19,748,943 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	19,641,297 - 19,651,611 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	19,581,889 - 19,592,200 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	19,581,891 - 19,592,200	NCBI
Celera	17	17,054,645 - 17,065,094 (-)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	19,020,080 - 19,030,532 (-)	NCBI		HuRef
CHM1_1	17	19,650,159 - 19,660,608 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	19,686,602 - 19,696,916 (-)	NCBI		T2T-CHM13v2.0

Aldh3a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	61,099,336 - 61,109,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	61,098,363 - 61,109,247 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	61,208,510 - 61,218,418 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	61,207,537 - 61,218,421 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	61,022,244 - 61,031,920 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	61,024,940 - 61,034,609 (+)	NCBI		MGSCv36	mm8
MGSCv36	11	61,638,438 - 61,648,107 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.96	NCBI

Aldh3a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	46,392,464 - 46,402,151 (+)	NCBI		GRCr8
mRatBN7.2	10	45,892,993 - 45,902,680 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,892,924 - 45,902,681 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	50,595,478 - 50,605,184 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	50,085,870 - 50,095,575 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	45,589,438 - 45,599,135 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	47,490,168 - 47,499,855 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	47,490,153 - 47,499,876 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	47,265,007 - 47,274,692 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	47,365,195 - 47,374,880 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	47,378,817 - 47,388,503 (+)	NCBI
Celera	10	45,146,398 - 45,156,083 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Aldh3a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	96,140 - 105,738 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	96,140 - 105,738 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDH3A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	54,728,524 - 54,738,858 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	59,540,244 - 59,550,581 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	31,384,740 - 31,395,719 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	36,531,830 - 36,539,428 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	36,531,720 - 36,542,504 (+)	Ensembl	panpan1.1		panPan2

ALDH3A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	40,466,237 - 40,474,272 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	40,466,237 - 40,474,457 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	40,608,116 - 40,616,150 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	40,572,237 - 40,580,273 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	40,572,237 - 40,580,458 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	40,543,623 - 40,551,653 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	40,489,252 - 40,497,281 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	40,681,916 - 40,689,952 (+)	NCBI		UU_Cfam_GSD_1.0

ALDH3A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	59,897,496 - 59,905,897 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	59,895,476 - 59,905,900 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	62,639,844 - 62,660,135 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH3A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	18,302,145 - 18,312,768 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	18,302,142 - 18,312,756 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	2,534,705 - 2,545,299 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000008506 ⟹ ENSSTOP00000007624

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936881	70,951 - 77,839 (+)	Ensembl

RefSeq Acc Id:

XM_021720941 ⟹ XP_021576616

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	60,509,720 - 60,516,217 (-)	NCBI
SpeTri2.0	NW_004936881	71,047 - 77,543 (+)	NCBI

Sequence:

show sequence

CTTCTTTCCAACCTCCTCCACCTTGCTGCAAGATCCCCTCTGTCCCTAGGTACCATGAGCAAGA
TCAGCGACGTGGTCAAGAGGGCCAGGGCCGCCTTCAACTCAGGCCTGACCCGCCCGCTGCAGTT
CCGGATCCAGCAGCTGGAGGCGCTGCGGCGCATGATCCAGGAGCGCCAGGCGGACATCACCGAG
GCTTTGGCCGCTGATCTGCACAAGAATGAATGGACCGCCTACGGTGAGGAGGTGGGGTACGTTC
TGGAGGAGATTGCGTATATGATCAAGAATCTCCATGAGTGGGTCAAGGATGAGCCTGTGGAAAA
GACTCCTGAGACCCAGCAGGATGAGTCCTACATCCACTCGGAGCCCCTGGGAGTGGTCCTCATC
ATTGGCACCTGGAACTACCCCTTCAACCTGGTTGTCCAGCCCATGGCGGGCGCCATTGCTGCAG
GGAATGCAGTGGTTCTCAAACCCTCAGAGCTGAGTGAGAACATGGCAAACCTGCTTGCCACCAT
CCTCCCTCAGTACATAGATAAGGAACTGTACCCAGTGATAAATGGGGGTGTCCCTGAGACCACA
GAGGTGCTCAAGGAGAGATTTGACCACATCTTCTACACGGGCAGCACGGGCGTAGGGAAGATTG
TTATGACAGCTGCTGCCAAGCACCTGACTCCTGTCACACTGGAACTGGGAGGAAAGAGCCCCTG
CTATGTGGACAAGGATTGCAATCTGGATGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATG
AACAGTGGCCAGACCTGTGTGGCCCCAGATTACATCCTTTGTGACCCCTCAATCCAGCACCAAA
TCGTGGAGAAACTAAAGAAGTCTCTGAAAGAGTTCTATGGGGAAGATGCCAAGAAGTCACGTGA
CTATGGAAGGATCATTAATGCCCGGCACTTCCAGAGGGTCATGGGGCTAATTGAGGGCCAGAAA
GTGGCCCATGGAGGCACTGGAGACATGGCCTCCCGCTACATAGCCCCCACCATCCTCACGGATG
TGGACCCCCAGTCCCAGGTGATGCAAGAGGAAATCTTTGGACCAGTGATGCCCATCGTGTGCGT
GCGCAGCCTGGAGGAAGCCATCCAGTTCATCAACCAGCGTGAGAAGCCCCTGGCTCTCTATGTC
TTCTCCAACAATAACAATGTGATTAAGAAGATGATCTCAGAGACATCAAGTGGCGGGGTGACAG
CCAACGACGTCATCGTACACATCACTGTGCACTCTCTGCCCTTCGGGGGCGTGGGGCACAGTGG
TATGGGGGCCTACCACGGCAGGAAGAGCTTCGAGACCTTCTCCCACCGCCGTTCTTGCCTGGTG
AGGTCTTTACTGAATGACGATGCCCACAAGGCCAGGTACCCACCAAGCCCAGCCAAGATGCCCT
GGCACTGAAGAGGGCCACTGCACCTGGCCTATCTGTGCCGTGCTGCCACCAGAGGATGAGACAC
CCTCGCTTGCTCTCCTACTCCTGGAGCTCCTGACTCTGGCCTCTTGCTTCTCTGCTCTCATAGG
CAAGCCCCCAACTCCCAGATGGACCCCAGGTCCCAGCGCTCCAAGACCCTTCCCCTTGCAAGAC
ACATAGGGACCAATAAAGGTTTCTGAACGGAAAGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021576616	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007624.2
GenBank Protein	KAG3270290	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021576616 ⟸ XM_021720941

- UniProtKB:

I3MBR7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSKISDVVKRARAAFNSGLTRPLQFRIQQLEALRRMIQERQADITEALAADLHKNEWTAYGEEV
GYVLEEIAYMIKNLHEWVKDEPVEKTPETQQDESYIHSEPLGVVLIIGTWNYPFNLVVQPMAGA
IAAGNAVVLKPSELSENMANLLATILPQYIDKELYPVINGGVPETTEVLKERFDHIFYTGSTGV
GKIVMTAAAKHLTPVTLELGGKSPCYVDKDCNLDVACRRIAWGKFMNSGQTCVAPDYILCDPSI
QHQIVEKLKKSLKEFYGEDAKKSRDYGRIINARHFQRVMGLIEGQKVAHGGTGDMASRYIAPTI
LTDVDPQSQVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNNNVIKKMISETSSG
GVTANDVIVHITVHSLPFGGVGHSGMGAYHGRKSFETFSHRRSCLVRSLLNDDAHKARYPPSPA
KMPWH

hide sequence

RefSeq Acc Id:

ENSSTOP00000007624 ⟸ ENSSTOT00000008506

Protein Domains

Aldehyde dehydrogenase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008487	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008506.3	UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/TrEMBL
	Aldehyde_DH_NAD(P)	UniProtKB/TrEMBL
NCBI Gene	LOC101970529	ENTREZGENE
PANTHER	ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING	UniProtKB/TrEMBL
	PTHR43570	UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/TrEMBL
PIRSF	ALDH	UniProtKB/TrEMBL
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53720	UniProtKB/TrEMBL
UniProt	I3MBR7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-07-13	Aldh3a1	aldehyde dehydrogenase 3 family member A1	LOC101970529	aldehyde dehydrogenase, dimeric NADP-preferring	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB