| 1309458 | Aldh1l2 | aldehyde dehydrogenase 1 family, member L2 | ENCODES a protein that exhibits formyltetrahydrofolate dehydrogenase activity (ortholog); INVOLVED IN 10-formyltetrahydrofolate catabolic process (ortholog); fatty acid beta-oxidation (ortholog); folic acid metabolic process (ortholog); PARTICIPATES IN folate mediated one-carbon metabolic pathway; A SSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran | 7 | 22141872 | 22193403 | Rat | 183 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1345617 | ALDH1L2 | aldehyde dehydrogenase 1 family member L2 | This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent react ion, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] | 12 | 105019790 | 105084458 | Human | 180 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551620 | Aldh1l2 | aldehyde dehydrogenase 1 family, member L2 | Enables formyltetrahydrofolate dehydrogenase activity. Involved in 10-formyltetrahydrofolate catabolic process; NADPH regeneration; and folic acid metabolic process. Acts upstream of or within with a positive effect on fatty acid beta-oxidation. Located in mitochondrion. Used to study metabolic dysf unction-associated steatotic liver disease. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 83320386 | 83370008 | Mouse | 194 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8722772 | Aldh1l2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits formyltetrahydrofolate dehydrogenase activity (ortholog); INVOLVED IN 10-formyltetrahydrofolate catabolic process (ortholog); fatty acid beta-oxidation (ortholog); folic acid metabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholo g); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | NW_004955405 | 39387949 | 39437282 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11772881 | ALDH1L2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Exper imental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred) | 12 | 102596881 | 102661617 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12171700 | ALDH1L2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Exper imental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred); INTERACTS WITH bisphenol A | 10 | 33310523 | 33365677 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12521702 | Aldh1l2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Exper imental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred) | NW_004936492 | 9605611 | 9657717 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13964818 | ALDH1L2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Exper imental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240716 | aldh1l2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626078497 | Aldh1l2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits formyltetrahydrofolate dehydrogenase activity (ortholog); INVOLVED IN 10-formyltetrahydrofolate catabolic process (ortholog); fatty acid beta-oxidation (ortholog); folic acid metabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholo g); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902513 | Aldh1l2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); mannosyltransferase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); folic acid metabolic process (ortholog); NADPH regeneration (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18557825 | ALDH1L2 | aldehyde dehydrogenase 1 family member L2 | ENCODES a protein that exhibits catalytic activity (inferred); formyltetrahydrofolate dehydrogenase activity (inferred); oxidoreductase activity (inferred); INVOLVED IN fatty acid beta-oxidation (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Exper imental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255509 | aldh1l2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240715 | aldh1l2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16561032 | AC008011.1 | pseudogene similar to part of aldehyde dehydrogenase 1 family, member L2 (ALDH1L2) | | | | | Human | | name | gene, unprocessed_pseudogene |