ALDH1L2 (aldehyde dehydrogenase 1 family member L2) - Rat Genome Database

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Gene: ALDH1L2 (aldehyde dehydrogenase 1 family member L2) Canis lupus familiaris
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Symbol: ALDH1L2
Name: aldehyde dehydrogenase 1 family member L2
RGD ID: 12171700
Description: ENCODES a protein that exhibits formyltetrahydrofolate dehydrogenase activity (inferred); hydroxymethyl-, formyl- and related transferase activity (inferred); oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (inferred); INVOLVED IN 10-formyltetrahydrofolate catabolic process (inferred); biosynthetic process (inferred); one-carbon metabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mitochondrial 10-formyltetrahydrofolate dehydrogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,310,523 - 33,365,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,310,558 - 33,365,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,229,898 - 33,285,026 (+)NCBI
ROS_Cfam_1.01034,151,792 - 34,207,579 (+)NCBI
UMICH_Zoey_3.11033,887,203 - 33,942,545 (+)NCBI
UNSW_CanFamBas_1.01034,171,323 - 34,226,449 (+)NCBI
UU_Cfam_GSD_1.01034,364,647 - 34,420,074 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Genomics

Comparative Map Data
ALDH1L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,310,523 - 33,365,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,310,558 - 33,365,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,229,898 - 33,285,026 (+)NCBI
ROS_Cfam_1.01034,151,792 - 34,207,579 (+)NCBI
UMICH_Zoey_3.11033,887,203 - 33,942,545 (+)NCBI
UNSW_CanFamBas_1.01034,171,323 - 34,226,449 (+)NCBI
UU_Cfam_GSD_1.01034,364,647 - 34,420,074 (+)NCBI
ALDH1L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12105,019,784 - 105,107,643 (-)EnsemblGRCh38hg38GRCh38
GRCh3812105,019,784 - 105,084,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712105,413,568 - 105,478,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612103,942,332 - 104,002,366 (-)NCBINCBI36hg18NCBI36
Celera12105,078,239 - 105,142,624 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12102,472,652 - 102,538,019 (-)NCBIHuRef
CHM1_112105,379,314 - 105,443,992 (-)NCBICHM1_1
Aldh1l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,320,386 - 83,370,008 (-)NCBIGRCm39mm39
GRCm39 Ensembl1083,323,314 - 83,370,004 (-)Ensembl
GRCm381083,487,447 - 83,534,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,487,450 - 83,534,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371082,950,192 - 82,996,885 (-)NCBIGRCm37mm9NCBIm37
MGSCv361082,917,249 - 82,963,861 (-)NCBImm8
Celera1085,474,860 - 85,521,640 (-)NCBICelera
Cytogenetic Map10C1NCBI
Aldh1l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2720,254,196 - 20,305,793 (+)NCBI
Rnor_6.0 Ensembl726,375,866 - 26,425,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0726,375,866 - 26,425,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0726,506,321 - 26,555,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,398,067 - 22,450,381 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1722,418,181 - 22,469,924 (+)NCBI
Celera717,456,470 - 17,507,229 (+)NCBICelera
Cytogenetic Map7q13NCBI
Aldh1l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,387,527 - 39,437,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540539,387,949 - 39,437,282 (-)NCBIChiLan1.0ChiLan1.0
ALDH1L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112105,992,398 - 106,046,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12105,997,045 - 106,056,607 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012102,596,881 - 102,661,617 (-)NCBIMhudiblu_PPA_v0panPan3
Aldh1l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494516,595,327 - 16,651,070 (+)NCBI
SpeTri2.0NW_0049364929,605,611 - 9,657,717 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,492,732 - 79,558,701 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1579,492,672 - 79,558,702 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,894,904 - 82,954,624 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,242,649 - 100,311,164 (-)NCBI
ChlSab1.1 Ensembl11100,247,262 - 100,298,621 (-)Ensembl
Vero_WHO_p1.0NW_023666037144,713,789 - 144,779,293 (+)NCBI
Aldh1l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247503,912,030 - 4,054,170 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 6 8 8 4
Low 5 1 11 1 6 1 6 6 4 10 2
Below cutoff 5 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003039   ⟹   ENSCAFP00000002821
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,310,558 - 33,365,228 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067045   ⟹   ENSCAFP00000055109
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1033,310,558 - 33,363,431 (+)Ensembl
RefSeq Acc Id: XM_038488846   ⟹   XP_038344774
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,887,203 - 33,942,545 (+)NCBI
RefSeq Acc Id: XM_038550810   ⟹   XP_038406738
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01034,364,647 - 34,420,074 (+)NCBI
RefSeq Acc Id: XM_038614730   ⟹   XP_038470658
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01034,171,323 - 34,226,449 (+)NCBI
RefSeq Acc Id: XM_038680098   ⟹   XP_038536026
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01034,151,792 - 34,207,579 (+)NCBI
RefSeq Acc Id: XM_531763   ⟹   XP_531763
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,310,523 - 33,365,677 (+)NCBI
Dog10K_Boxer_Tasha1033,229,898 - 33,285,026 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038344774 (Get FASTA)   NCBI Sequence Viewer  
  XP_038406738 (Get FASTA)   NCBI Sequence Viewer  
  XP_038470658 (Get FASTA)   NCBI Sequence Viewer  
  XP_038536026 (Get FASTA)   NCBI Sequence Viewer  
  XP_531763 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_531763   ⟸   XM_531763
- Peptide Label: isoform X1
- UniProtKB: E2RC62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002821   ⟸   ENSCAFT00000003039
RefSeq Acc Id: ENSCAFP00000055109   ⟸   ENSCAFT00000067045
RefSeq Acc Id: XP_038344774   ⟸   XM_038488846
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470658   ⟸   XM_038614730
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038536026   ⟸   XM_038680098
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038406738   ⟸   XM_038550810
- Peptide Label: isoform X2
Protein Domains
Carrier

Promoters
RGD ID:13685008
Promoter ID:EPDNEW_C3075
Type:initiation region
Name:ALDH1L2_1
Description:aldehyde dehydrogenase 1 family member L2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11033,310,532 - 33,310,592EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000002821 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000055109 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003039 UniProtKB/TrEMBL
  ENSCAFT00000067045 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.10 UniProtKB/TrEMBL
  3.10.25.10 UniProtKB/TrEMBL
  3.40.309.10 UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/TrEMBL
InterPro 10_FTHF_DH UniProtKB/TrEMBL
  ACP-like_sf UniProtKB/TrEMBL
  Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
  Formyl_trans_C UniProtKB/TrEMBL
  Formyl_trans_C_sf UniProtKB/TrEMBL
  Formyl_transf_N UniProtKB/TrEMBL
  Formyl_transf_N_sf UniProtKB/TrEMBL
  Formyl_transferase_C-like UniProtKB/TrEMBL
  GART_AS UniProtKB/TrEMBL
  PP-bd_ACP UniProtKB/TrEMBL
  Ppantetheine_attach_site UniProtKB/TrEMBL
KEGG Report cfa:474534 UniProtKB/TrEMBL
NCBI Gene ALDH1L2 ENTREZGENE
Pfam Aldedh UniProtKB/TrEMBL
  Formyl_trans_C UniProtKB/TrEMBL
  Formyl_trans_N UniProtKB/TrEMBL
  PP-binding UniProtKB/TrEMBL
PIRSF 10-FTHFDH UniProtKB/TrEMBL
PROSITE ACP_DOMAIN UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_CYS UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/TrEMBL
  GART UniProtKB/TrEMBL
  PHOSPHOPANTETHEINE UniProtKB/TrEMBL
Superfamily-SCOP SSF47336 UniProtKB/TrEMBL
  SSF50486 UniProtKB/TrEMBL
  SSF53328 UniProtKB/TrEMBL
  SSF53720 UniProtKB/TrEMBL
UniProt A0A5F4CLG3_CANLF UniProtKB/TrEMBL
  E2RC62 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37785 ENTREZGENE