| 1345768 | AGBL1 | AGBL carboxypeptidase 1 | Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013] | 15 | 86079620 | 87031476 | Human | 70 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1560280 | Agbl1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits metallocarboxypeptidase activity (ortholog); tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dy strophy (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH alpha-Zearalanol; atrazine; bisphenol A | 1 | 139453667 | 140360473 | Rat | 60 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1616513 | Agbl1 | ATP/GTP binding protein-like 1 | Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in C-terminal protein deglutamylation and protein side chain deglutamylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, incl uding central nervous system; early embryo; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to human AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 75879311 | 76774446 | Mouse | 71 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8926719 | Agbl1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits metallocarboxypeptidase activity (ortholog); tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dy strophy (ortholog) | NW_004955416 | 17885757 | 18686124 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11894676 | AGBL1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferre d) | 15 | 64774408 | 65603628 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12175145 | AGBL1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (orthol og); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferred) | 3 | 49639425 | 50331421 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12582873 | Agbl1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferre d) | NW_004936483 | 12358731 | 13056267 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18532793 | AGBL1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferre d) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625904724 | Agbl1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits metallocarboxypeptidase activity (ortholog); tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dy strophy (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14085592 | AGBL1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (orthol og); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferred) | | | | Pig | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908607 | Agbl1 | AGBL carboxypeptidase 1 | ENCODES a protein that exhibits tubulin binding (ortholog); INVOLVED IN C-terminal protein deglutamylation (ortholog); protein side chain deglutamylation (ortholog); ASSOCIATED WITH Corneal Dystrophy, Fuchs Endothelial, 8 (ortholog); Fuchs' endothelial dystrophy (ortholog); FOUND IN cytosol (inferre d) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247614 | agbl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155231805 | agbl1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254391 | agbl1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7244440 | AGBL1-AS1 | AGBL1 antisense RNA 1 | | 15 | 86296833 | 86316968 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16562382 | AC012229.1 | novel transcript, antisense to AGBL1 | | | | | Human | | name | gene, lncrna |
| 16562311 | AC016987.1 | novel transcript, antisense to AGBL1 | | 15 | 86938797 | 86988426 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
