| 2036 | Adcy8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; INVOLVED IN activation of protein kinase A activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton; caveola; clathrin-coated pit; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine | 7 | 98306434 | 98555687 | Rat | 261 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733733 | ADCY8 | adenylate cyclase 8 | Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibi tory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] | 8 | 130780301 | 131040909 | Human | 214 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736586 | Adcy8 | adenylate cyclase 8 | Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cellular response to glucagon stimulus; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular compo nents, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; nephrogenic zone; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 64570884 | 64794145 | Mouse | 229 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8760506 | Adcy8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); axon (ortholog) | NW_004955461 | 5497708 | 5725574 | Chinchilla | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11809136 | ADCY8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); plasma membrane raft (ortholog) | 8 | 127418407 | 127681217 | Bonobo | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12178253 | ADCY8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); plasma membrane raft (ortholog) | 13 | 27723530 | 27937821 | Dog | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12651607 | Adcy8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); plasma membrane raft (ortholog) | NW_004936470 | 17831644 | 18047868 | Squirrel | 112 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14106976 | ADCY8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); plasma membrane raft (ortholog) | | | | Pig | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625983262 | Adcy8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Black Rat | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083151 | adcy8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18363814 | ADCY8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); plasma membrane raft (ortholog) | | | | Green Monkey | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901305 | Adcy8 | adenylate cyclase 8 | ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN activation of protein kinase A activity (ortholog); cAMP biosynthetic process (ortholog); cAMP/PKA signal transduction (ortho log); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); Hyperkinesis (ortholog); mood disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); excitatory synapse (ortholog) | | | | Naked Mole-Rat | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083152 | adcy8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288077857 | adcy8.S | | | | | | African Clawed Frog | | symbol | gene, null |