ADCY8 (adenylate cyclase 8) - Rat Genome Database

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Gene: ADCY8 (adenylate cyclase 8) Chlorocebus sabaeus
Analyze
Symbol: ADCY8
Name: adenylate cyclase 8
RGD ID: 18363814
Description: ENCODES a protein that exhibits actin binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); calmodulin binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP-mediated signaling (ortholog); cellular response to calcium ion (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH diabetic angiopathy (ortholog); genetic disease (ortholog); Hyperkinesis (ortholog); FOUND IN actin cytoskeleton (ortholog); caveola (ortholog); clathrin-coated pit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase type 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18125,269,396 - 125,535,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8125,269,736 - 125,533,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603914,582,569 - 14,845,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCY8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18125,269,396 - 125,535,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8125,269,736 - 125,533,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603914,582,569 - 14,845,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ADCY8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388130,780,301 - 131,040,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8130,780,301 - 131,040,909 (-)EnsemblGRCh38hg38GRCh38
GRCh378131,792,547 - 132,053,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368131,861,729 - 132,123,854 (-)NCBINCBI36Build 36hg18NCBI36
Build 348131,861,728 - 132,123,854NCBI
Celera8127,969,937 - 128,230,969 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8127,112,105 - 127,216,470 (-)NCBIHuRef
HuRef8127,235,506 - 127,372,263 (-)NCBIHuRef
CHM1_18131,833,662 - 132,093,872 (-)NCBICHM1_1
T2T-CHM13v2.08131,907,547 - 132,167,269 (-)NCBIT2T-CHM13v2.0
Adcy8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391564,570,884 - 64,794,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1564,568,933 - 64,794,145 (-)EnsemblGRCm39 Ensembl
GRCm381564,699,035 - 64,922,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1564,697,084 - 64,922,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv371564,530,597 - 64,753,858 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361564,528,707 - 64,751,833 (-)NCBIMGSCv36mm8
Celera1566,221,302 - 66,448,865 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.03NCBI
Adcy8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8798,306,434 - 98,555,687 (-)NCBIGRCr8
mRatBN7.2796,417,310 - 96,665,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx798,176,363 - 98,425,655 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07100,377,999 - 100,627,320 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07100,299,283 - 100,548,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
Adcy8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554615,497,628 - 5,725,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554615,497,708 - 5,725,574 (-)NCBIChiLan1.0ChiLan1.0
ADCY8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27148,150,875 - 148,412,746 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18123,667,241 - 123,929,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08127,418,407 - 127,681,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18130,399,223 - 130,661,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8130,398,288 - 130,661,073 (-)Ensemblpanpan1.1panPan2
ADCY8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11327,723,530 - 27,937,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1327,723,530 - 27,937,734 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1327,690,009 - 27,910,417 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01328,068,919 - 28,289,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1328,068,921 - 28,289,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11327,784,095 - 28,006,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01327,904,105 - 28,118,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01328,205,442 - 28,426,573 (-)NCBIUU_Cfam_GSD_1.0
Adcy8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530310,405,531 - 10,621,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647017,831,639 - 18,047,868 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647017,831,644 - 18,047,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl49,645,659 - 9,866,550 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.149,645,398 - 9,867,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.249,777,859 - 9,968,857 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Adcy8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473524,891,583 - 25,149,900 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473524,891,803 - 25,149,817 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 8
Low 14 12 46
Below cutoff 6 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008169   ⟹   ENSCSAP00000006321
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl8125,269,736 - 125,533,015 (-)Ensembl
RefSeq Acc Id: XM_008001549   ⟹   XP_007999740
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.18125,269,684 - 125,535,806 (-)NCBI
Vero_WHO_p1.0NW_02366603914,582,569 - 14,845,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001550   ⟹   XP_007999741
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.18125,269,396 - 125,533,989 (-)NCBI
Vero_WHO_p1.0NW_02366603914,584,655 - 14,845,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001551   ⟹   XP_007999742
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.18125,269,396 - 125,533,990 (-)NCBI
Vero_WHO_p1.0NW_02366603914,583,442 - 14,845,875 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007999740 (Get FASTA)   NCBI Sequence Viewer  
  XP_007999741 (Get FASTA)   NCBI Sequence Viewer  
  XP_007999742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006321
  ENSCSAP00000006321.1
Reference Protein Sequences
RefSeq Acc Id: XP_007999742   ⟸   XM_008001551
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RCI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007999741   ⟸   XM_008001550
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RCI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007999740   ⟸   XM_008001549
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RCI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006321   ⟸   ENSCSAT00000008169


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010082 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008169.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
NCBI Gene ADCY8 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 8 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt A0A0D9RCI2 ENTREZGENE, UniProtKB/TrEMBL