| 70911 | Acvr2a | activin A receptor type 2A | ENCODES a protein that exhibits activin binding; inhibin binding; activin receptor activity (ortholog); INVOLVED IN adrenal gland development; autophagy; cellular response to oxygen-glucose deprivation; PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; transforming grow th factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH cocaine dependence; Experimental Liver Cirrhosis; Femoral Fractures; FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; ammonium chloride | 3 | 53614143 | 53701933 | Rat | 191 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731811 | ACVR2A | activin A receptor type 2A | This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013] | 2 | 147844517 | 147930822 | Human | 163 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550139 | Acvr2a | activin receptor IIA | Enables several functions, including PDZ domain binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in BMP signaling pathway. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and regi onalization. Located in cell surface. Is active in plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 48704121 | 48793276 | Mouse | 283 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8793544 | Acvr2a | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity (ortholog); activin receptor activity, type I (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); PARTIC IPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog) | NW_004955440 | 13849926 | 13931374 | Chinchilla | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11792765 | ACVR2A | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); inhibin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog ); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN activin receptor complex (inferred); cell surface (inferred); cytoplasm (inferred) | 2B | 11933683 | 12020287 | Bonobo | 106 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12323815 | ACVR2A | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity (ortholog); activin receptor activity, type I (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signali ng pathway; ASSOCIATED WITH cocaine dependence (ortholog); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog); INTERACTS WITH bisphenol A | 19 | 49642429 | 49726720 | Dog | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12599502 | Acvr2a | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); inhibin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog ); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN activin receptor complex (inferred); cell surface (inferred); cytoplasm (inferred) | NW_004936469 | 29195329 | 29273237 | Squirrel | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625965984 | Acvr2a | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity (ortholog); activin receptor activity, type I (ortholog); INVOLVED IN activin receptor signaling pathway (ortholog); adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); PARTIC IPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog) | | | | Black Rat | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14004399 | ACVR2A | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); inhibin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog ); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); inhibin-betaglycan-ActRII complex (inferred) | | | | Pig | 101 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18590183 | ACVR2A | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); inhibin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH cocaine dependence (ortholog ); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN activin receptor complex (inferred); cell surface (inferred); cytoplasm (inferred) | | | | Green Monkey | 106 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239906 | acvr2a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18901890 | Acvr2a | activin A receptor type 2A | ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity (ortholog); activin receptor activity, type I (ortholog); INVOLVED IN adrenal gland development (ortholog); anterior/posterior pattern specification (ortholog); autophagy (ortholog); PARTICIPATES IN activin signali ng pathway; ASSOCIATED WITH cocaine dependence (ortholog); colon cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); inhibin-betaglycan-ActRII complex (ortholog) | | | | Naked Mole-Rat | 102 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245826 | acvr2a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239905 | acvr2a.S | | | | | | African Clawed Frog | | symbol | gene, null |