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Gene: ACVR2A (activin A receptor type 2A) Homo sapiens
Symbol: ACVR2A
Name: activin A receptor type 2A
Description: Exhibits coreceptor activity and protein serine/threonine kinase activity. Contributes to activin binding activity and activin-activated receptor activity. Involved in several processes, including positive regulation of ossification; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytoplasm; inhibin-betaglycan-ActRII complex; and receptor complex. Implicated in colon cancer. Biomarker of pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activin A receptor type IIA; activin A receptor, type IIA; activin receptor iia; activin receptor type-2A; ACTRII; ACVR2
Mus musculus (house mouse) : Acvr2a (activin receptor IIA)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acvr2a (activin A receptor type 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acvr2a (activin A receptor type 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : ACVR2A (activin A receptor type 2A)
Canis lupus familiaris (dog) : ACVR2A (activin A receptor type 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acvr2a (activin A receptor type 2A)
Sus scrofa (pig) : ACVR2A (activin A receptor type 2A)
Chlorocebus sabaeus (African green monkey) : ACVR2A (activin A receptor type 2A)
Heterocephalus glaber (naked mole-rat) : Acvr2a (activin A receptor type 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2147,844,517 - 147,930,826 (+)EnsemblGRCh38hg38GRCh38
GRCh382147,844,517 - 147,930,827 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372148,602,086 - 148,688,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,319,040 - 148,404,863 (+)NCBINCBI36hg18NCBI36
Build 342148,436,303 - 148,519,242NCBI
Celera2142,316,710 - 142,402,536 (+)NCBI
Cytogenetic Map2q22.3-q23.1NCBI
HuRef2140,599,673 - 140,685,765 (+)NCBIHuRef
CHM1_12148,607,725 - 148,694,041 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACVR2A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731811
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.