| 1306246 | Acss1 | acyl-CoA synthetase short-chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity; propionate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process; propionate biosynthetic process; acetyl-CoA biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradat ion pathway; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 3 | 159910809 | 159960748 | Rat | 176 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314754 | ACSS1 | acyl-CoA synthetase short chain family member 1 | This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this ge ne. [provided by RefSeq, Nov 2011] | 20 | 25006237 | 25058139 | Human | 181 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1615097 | Acss1 | acyl-CoA synthetase short-chain family member 1 | Enables acetate-CoA ligase activity and propionate-CoA ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 150460031 | 150510160 | Mouse | 197 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8980917 | Acss1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); propionate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | NW_004955415 | 31117542 | 31154654 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11707166 | ACSS1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathwa y; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | 20 | 24946629 | 25001311 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12284658 | ACSS1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathwa y; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrion (ortholog) | 23 | 1192771 | 1251724 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12626010 | Acss1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathwa y; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | NW_004936620 | 739633 | 800472 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13993445 | ACSS1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathwa y; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH copper(II) sulfate; quercetin | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626063355 | Acss1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); propionate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247550 | acss1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18913798 | Acss1 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); propionate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); Hypothermia (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245618 | acss1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239696 | acss1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18760888 | LOC103247057 | acyl-CoA synthetase short chain family member 1 | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); propionate-CoA ligase activity (ortholog); INVOLVED IN acetate biosynthetic process (ortholog); acetyl-CoA biosynthetic process (ortholog); propionate biosynthetic process (ortholog); ASSOCIATED WITH Hypothermia (ortholog); FOUN D IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Green Monkey | 14 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 40894588 | LOC119618631 | acetyl-coenzyme A synthetase 2-like, mitochondrial | ENCODES a protein that exhibits acetate-CoA ligase activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog) | | | | Green Monkey | 13 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |