Strain Report - Rat Genome Database

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Strain: FHH/Eur

Symbol: FHH/Eur
Strain: FHH
Substrain: Eur
RGD ID: 10015
Citation ID: RRID:RGD_10015
Ontology ID: RS:0000018
Type: inbred
Available Source: Not Available
Origination: Erasmus University-Rotterdam
Description: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Brown DM, etal., Nat Genet 1996 Jan;12(1):44-51
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.
6. Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. Shiozawa M, etal., J Am Soc Nephrol 2000 Nov;11(11):2068-78.
7. Pathogenesis of glomerular injury in the fawn-hooded rat: early glomerular capillary hypertension predicts glomerular sclerosis. Simons JL, etal., J Am Soc Nephrol 1993 May;3(11):1775-82.
8. A high density integrated genetic linkage and radiation hybrid map of the laboratory rat Steen RG, Kwitek-Black AE, etal., Genome Research, 1999, 6:1-8
9. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. van Dokkum RP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R855-63


Strain QTL Data
Symbol Name Trait
Bp283 Blood pressure QTL 283 arterial blood pressure trait   (VT:2000000)    
Rf1 Renal disease susceptibility QTL 1 urine protein amount   (VT:0005160)    
Rf3 Renal disease susceptibility QTL 3 urine albumin amount   (VT:0002871)    
Rf4 Renal disease susceptibility QTL 4 urine total protein amount   (VT:0000032)    
Rf5 Renal disease susceptibility QTL 5 urine total protein amount   (VT:0000032)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These animals have a characteristic early presence of systolic and glomerular hypertension progressive proteinuria (UPV) and albuminuria (UAV) and focal glomerulosclerosis which results in renal failure leading to premature death. 1016