RGD Reference Report - Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. - Rat Genome Database
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Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

Authors: Brown, DM  Provoost, AP  Daly, MJ  Lander, ES  Jacob, HJ 
Citation: Brown DM, etal., Nat Genet 1996 Jan;12(1):44-51
RGD ID: 61060
Pubmed: (View Article at PubMed) PMID:8528250
DOI: Full-text: DOI:10.1038/ng0196-44

Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the fawn-hooded rat, an animal model of hypertension that develops chronic renal failure. Here, we report the localization of two genes, Rf-1 and Rf-2, responsible for about half of the genetic variation in key indices of renal impairment. In addition, we localize a gene, Bpfh-1, responsible for about 26% of the genetic variation in blood pressure. Rf-1 strongly affects the risk of renal impairment, but has no significant effect on blood pressure. Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp197  (Blood pressure QTL 197)
Rf1  (Renal disease susceptibility QTL 1)
Rf2  (Renal disease susceptibility QTL 2)

Objects referenced in this article
0 D1Mgh12 D1Mgh12 All species
0 D1Mit6 D1Mit6 All species
0 D1Mit3 D1Mit3 All species
0 D1Mit2 D1Mit2 All species
0 ACI/N A X C 9935, Irish All species
0 Bp26 Blood pressure QTL 26 All species
0 Bp28 Blood pressure QTL 28 All species
0 Bp29 Blood pressure QTL 29 All species
0 Bp30 Blood pressure QTL 30 All species
0 FHH Fawn Hooded Hypertensive All species
0 Mt1-ps1 metallothionein 1, pseudogene 1 All species

Additional Information