RGD Reference Report - Mice lacking Ran binding protein 1 are viable and show male infertility. - Rat Genome Database

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Mice lacking Ran binding protein 1 are viable and show male infertility.

Authors: Nagai, M  Moriyama, T  Mehmood, R  Tokuhiro, K  Ikawa, M  Okabe, M  Tanaka, H  Yoneda, Y 
Citation: Nagai M, etal., FEBS Lett. 2011 Mar 9;585(5):791-6. doi: 10.1016/j.febslet.2011.02.002. Epub 2011 Feb 26.
RGD ID: 9835350
Pubmed: PMID:21310149   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2011.02.002   (Journal Full-text)

The small GTPase Ran plays important roles in multiple aspects of cellular function. Maximal RanGAP activity is achieved with the aid of RanBP1 and/or presumably of RanBP2. Here, we show that RanBP1-knockout mice are unexpectedly viable, and exhibit male infertility due to a spermatogenesis arrest, presumably caused by down-regulation of RanBP2 during spermatogenesis. Indeed, siRNA-mediated depletion of RanBP2 caused severe cell death only in RanBP1-deficient MEFs, indicating that simultaneous depletion of RanBP1 and RanBP2 severely affects normal cell viability. Collectively, we conclude that the dramatic decrease in "RanBP" activity impairs germ cell viability and affects spermatogenesis decisively in RanBP1-knockout mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RANBP2Humanmale infertility  ISORanbp2 (Mus musculus) RGD 
Ranbp2Mousemale infertility  IMP  RGD 
Ranbp2Ratmale infertility  ISORanbp2 (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ranbp2  (RAN binding protein 2)

Genes (Mus musculus)
Ranbp2  (RAN binding protein 2)

Genes (Homo sapiens)
RANBP2  (RAN binding protein 2)


Additional Information