RGD Reference Report - Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their Fc gamma IIb receptor. - Rat Genome Database

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Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their Fc gamma IIb receptor.

Authors: Mihaylova, N  Voynova, E  Tchorbanov, A  Nikolova, M  Michova, A  Todorov, T  Srebreva, L  Taskov, H  Vassilev, T 
Citation: Mihaylova N, etal., Int Immunol. 2008 Feb;20(2):165-75. Epub 2007 Dec 21.
RGD ID: 9588566
Pubmed: PMID:18156625   (View Abstract at PubMed)
DOI: DOI:10.1093/intimm/dxm133   (Journal Full-text)

The presently used approaches to silence autoreactive disease-associated B cells act indiscriminately and more specific therapies are obviously needed. In the present study, we analyze the ability of a chimeric antibody to suppress selectively pathological autoreactive B-lymphocytes in lupus-prone mice by cross-linking their surface Ig receptors with the inhibitory IgG Fc gamma RIIb receptors. The chimera was constructed by coupling an immunodominant mouse Histone 1 peptide to a rat monoclonal anti-mouse CD32 (Fc gamma RIIb) antibody. The administration of these chimeric molecules to MRL/lpr mice with initial and with full-blown disease resulted in the reduction of the levels of IgG anti-Histone 1 antibodies, of the albuminuria levels, of the size of lymphoid organs and in prevention of the development of skin lesions. The observed effect was limited to lupus-associated B cells only, as the treatment did not decrease the IgG antibody response to an administered foreign antigen. This study demonstrates the possibility to silence selectively autoreactive B cells and to delay the progression of an autoimmune disease using chimeric antibody molecules.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2BHumansystemic lupus erythematosus treatmentISOFcgr2b (Mus musculus) RGD 
Fcgr2bRatsystemic lupus erythematosus treatmentISOFcgr2b (Mus musculus) RGD 
Fcgr2bMousesystemic lupus erythematosus treatmentIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2b  (Fc gamma receptor 2B)

Genes (Mus musculus)
Fcgr2b  (Fc receptor, IgG, low affinity IIb)

Genes (Homo sapiens)
FCGR2B  (Fc gamma receptor IIb)


Additional Information