RGD Reference Report - Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians.

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Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians.
Authors:	Mitra, AK Singh, SV Garg, VK Sharma, M Chaturvedi, R Rath, SK
Citation:	Mitra AK, etal., Indian J Med Res. 2011 Jun;133:605-12.
RGD ID:	8657147
Pubmed:	PMID:21727658 (View Abstract at PubMed)
PMCID:	PMC3135987 (View Article at PubMed Central)
BACKGROUND & OBJECTIVES: Imbalances in compactly regulated DNA repair pathways in the form of single nucleotide polymorphisms (SNPs) within vital DNA repair genes may result in insufficient DNA repair and increase in DNA breaks thus rendering the human system vulnerable to the debilitatory effects of grave diseases like cancers. The present study involves investigation of association of the non-synonymous SNP rs1052133 (C8069G/Ser326Cys) located in the exonic region of the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head and neck (SCCHN). METHODS: Case-control based genetic association study was performed among 575 (250 SCCHN cases and 325 normal healthy controls) sub-population cluster-matched (Indo-Europeans linguistic subgroup + Caucasoid morphological subtype) samples from the north Indian States of Uttar Pradesh and Uttarakhand using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis. RESULTS: Our results demonstrated statistically significant protective association for the heterozygous CG [Odds Ratio (OR) 0.6587, 95% Confidence Interval (CI) 0.4615 to 0.9402, P=0.0238], homozygous mutant GG (OR 0.2570, 95% CI 0.1070 to 0.6175, P=0.0013) and combined mutant CG + GG (OR 0.6057, 95% CI 0.4272 to 0.8586, P=0.0059) genotypes. INTERPRETATION & CONCLUSIONS: The results indicate that the polymorphism rs1052133 is strongly associated with SCCHN susceptibility and the mutant (G) allele might be a protective factor for SCCHN among north Indian subpopulations.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
OGG1	Human	head and neck squamous cell carcinoma	susceptibility	IAGP		DNA:SNP: :rs1052133 (human)	RGD
Ogg1	Rat	head and neck squamous cell carcinoma	susceptibility	ISO	OGG1 (Homo sapiens)	DNA:SNP: :rs1052133 (human)	RGD
Ogg1	Mouse	head and neck squamous cell carcinoma	susceptibility	ISO	OGG1 (Homo sapiens)	DNA:SNP: :rs1052133 (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ogg1 (8-oxoguanine DNA glycosylase)

Genes (Mus musculus)

Ogg1 (8-oxoguanine DNA-glycosylase 1)

Genes (Homo sapiens)

OGG1 (8-oxoguanine DNA glycosylase)

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Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians.