RGD Reference Report - Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus. - Rat Genome Database

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Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus.

Authors: Hu, JY  Zhang, J  Cui, JL  Liang, XY  Lu, R  Du, GF  Xu, XY  Zhou, G 
Citation: Hu JY, etal., Cytokine. 2013 Apr;62(1):141-5. doi: 10.1016/j.cyto.2013.01.020. Epub 2013 Mar 9.
RGD ID: 8551821
Pubmed: PMID:23490419   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2013.01.020   (Journal Full-text)

Oral lichen planus (OLP) is a T cell-mediated autoimmune disease of oral mucosa, in which T helper 1 (Th1) cells are greatly involved. Chemokine CCL5 is required for T cells infiltration and activation. CCR5, one of its receptors, specifically expressed on Th1 cells among CD4(+) T cells, can be up-regulated by Th1 cytokines like interleukin2 (IL-2) and interferon-gamma (IFN-gamma), and down-regulated by Th2 cytokines like IL-4. The present study aimed to determine whether CCL5 and CCR5 had effects on the immune response of OLP. We analyzed the proportion of CCR5(+)CD4(+) T cells in CD4(+) T cells using flow cytometry and the serum levels of CCL5, IL-2, IFN-gamma, and IL-4 with ELISA. MicroRNA-125a (miR-125a), a blocker of CCL5, was examined with RT-PCR. The results showed both the serum CCL5 and the percentage of CCR5(+)CD4(+) T cells elevated in OLP patients. Serum IL-2 and IFN-gamma increased in OLP patients, but IL-4 decreased. MiR-125a was down-regulated in OLP patients, and there was a negative correlation between miR-125a content and the OLP severity which was measured with a RAE (reticular, atrophic and erosive lesion) scoring system. In conclusion, increasing CCl5/CCR5 might participate in the immune response of OLP. Th1-type cytokines environment presented in OLP probably performed as a magnifier for the CCR5. Moreover, miR-125a might be a candidate biomarker to estimate the severity of OLP.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR5HumanOral Lichen Planus  IEP protein:increased expression:blood and T cellRGD 
Ccr5RatOral Lichen Planus  ISOCCR5 (Homo sapiens)protein:increased expression:blood and T cellRGD 
Ccr5MouseOral Lichen Planus  ISOCCR5 (Homo sapiens)protein:increased expression:blood and T cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information