RGD Reference Report - Effect of the chemokine receptor CCR5 in the development of American cutaneous leishmaniasis in a Southern Brazilian population. - Rat Genome Database

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Effect of the chemokine receptor CCR5 in the development of American cutaneous leishmaniasis in a Southern Brazilian population.

Authors: Ribas, AD  Ribas, RC  Da Silva Junior, WV  Aristides, SM  Lonardoni, MV  Watanabe, MA  Borelli, SD  Silveira, TG 
Citation: Ribas AD, etal., Mol Med Rep. 2013 Jul;8(1):189-94. doi: 10.3892/mmr.2013.1452. Epub 2013 Apr 30.
RGD ID: 8549764
Pubmed: PMID:23632983   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2013.1452   (Journal Full-text)

American cutaneous leishmaniasis (ACL) shows a wide spectrum of clinical and immunopathological manifestations. The CCR5 chemokine receptor directs the immune response to a Th1 pattern and the mutant allele of this genotype (Delta32/Delta32) results in a less effective response, thus leading to a milder inflammation. The objective of the present study was to investigate the effect of the CCR5 chemokine receptor in the pathogenesis of ACL in a population of Southern Brazil. The frequency of the genotypes and their association with ACL were studied in 111 patients and compared with 218 control subjects. Genotyping was performed using samples amplified by polymerase chain reaction with sequence specific primers (PCRSSP). The groups varied in chronological age (P<0.00001), but showed no differences in gender (P=0.0696) or ethnicity (P=0.2944). The frequency of the CCR5/Delta32 genotype did not differ between the patient and control groups (P=0.3009). The Delta32/Delta32 deletion was not observed in any individual involved in the study. The analysis of the genotypes observed no significant difference in the frequency of the CCR5/Delta32 genotype between the ACL and control groups, however the subgroup of patients with a recurrence of the lesion showed a higher frequency of the CCR5/Delta32 mutation (P=0.020), indicating a possible effect of this allele in the pathogenesis of ACL. Nevertheless, more studies are required to elucidate the role of CCR5 in the pathogenesis of ACL.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR5Humancutaneous leishmaniasis  IAGP DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 
Ccr5Ratcutaneous leishmaniasis  ISOCCR5 (Homo sapiens)DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 
Ccr5Mousecutaneous leishmaniasis  ISOCCR5 (Homo sapiens)DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information