RGD Reference Report - Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats. - Rat Genome Database

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Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats.

Authors: Facio FN, JR  Sena, AA  Araujo, LP  Mendes, GE  Castro, I  Luz, MA  Yu, L  Oliani, SM  Burdmann, EA 
Citation: Facio FN Jr, etal., J Mol Med (Berl). 2011 Jan;89(1):51-63. doi: 10.1007/s00109-010-0684-4. Epub 2010 Oct 16.
RGD ID: 7421585
Pubmed: PMID:20953576   (View Abstract at PubMed)
DOI: DOI:10.1007/s00109-010-0684-4   (Journal Full-text)

Inflammation is currently recognized as a key mechanism in the pathogenesis of renal ischemia-reperfusion (I/R) injury. The importance of infiltrating neutrophil, lymphocytes, and macrophage in this kind of injury has been assessed with conflicting results. Annexin 1 is a protein with potent neutrophil anti-migratory activity. In order to evaluate the effects of annexin A1 on renal I/R injury, uninephrectomized rats received annexin A1 mimetic peptide Ac2-26 (100 mug) or vehicle before 30 min of renal artery clamping and were compared to sham surgery animals. Annexin A1 mimetic peptide granted a remarkable protection against I/R injury, preventing glomerular filtration rate and urinary osmolality decreases and acute tubular necrosis development. Annexin A1 infusion aborted neutrophil extravasation and attenuated macrophage infiltration but did not prevent tissue lymphocyte traffic. I/R increased annexin A1 expression (assessed by transmission electron microscopy) in renal epithelial cells, which was attenuated by exogenous annexin A1 infusion. Additionally, annexin A1 reduced I/R injury in isolated proximal tubules suspension. Annexin A1 protein afforded striking functional and structural protection against renal I/R. These results point to an important role of annexin A1 in the epithelial cells defense against I/R injury and indicate that neutrophils are key mediators for the development of tissue injury after renal I/R. If these results were confirmed in clinical studies, annexin A1 might emerge as an important tool to protect against I/R injury in renal transplantation and in vascular surgery.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANXA1HumanKidney Reperfusion Injury treatmentISOAnxa1 (Rattus norvegicus) RGD 
Anxa1RatKidney Reperfusion Injury treatmentIDA  RGD 
Anxa1MouseKidney Reperfusion Injury treatmentISOAnxa1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa1  (annexin A1)

Genes (Mus musculus)
Anxa1  (annexin A1)

Genes (Homo sapiens)
ANXA1  (annexin A1)