RGD Reference Report - Chronic rhinosinusitis with nasal polyps: a proteomic analysis. - Rat Genome Database

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Chronic rhinosinusitis with nasal polyps: a proteomic analysis.

Authors: Upton, DC  Welham, NV  Kuo, JS  Walker, JW  Pasic, TR 
Citation: Upton DC, etal., Ann Otol Rhinol Laryngol. 2011 Dec;120(12):780-6.
RGD ID: 7421555
Pubmed: PMID:22279949   (View Abstract at PubMed)

OBJECTIVES: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a severe subtype of chronic rhinosinusitis that can affect patients despite medical and surgical interventions. The purpose of this study was to utilize the techniques of proteomics to investigate differences in protein abundance within the sinonasal mucosa of patients with CRSwNP compared to healthy controls. METHODS: In a case-control study at a tertiary-care academic medical center, sinonasal mucosa was harvested from 3 patients with CRSwNP and 3 control patients undergoing transsphenoidal excision of pituitary tumors. Two-dimensional gel electrophoresis was used to identify proteins with elevated or reduced abundance in CRSwNP patients compared to controls. The proteins showing the greatest abundance differences were characterized by mass spectrometry. RESULTS: More than 300 differentially abundant proteins (p < or = 0.05) were identified. Many of these protein species were involved in the host inflammatory response. Proteins up-regulated in CRSwNP patients included eosinophil lysophospholipase by a ratio (R) of 18.13, RHO-GDP dissociation inhibitor 2 (R = 2.80), and apolipoprotein A-1 (R = 1.73). Down-regulated proteins in CRSwNP patients included catalase (R = -5.87), annexin A1 (R = -6.27), and keratin II-8 (R = -6.73). A detailed analysis of additional protein species is outlined. CONCLUSIONS: The proteomic approach allows detection of significant differences in protein abundance in CRSwNP and provides unique insight into the pathophysiology of this common disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANXA1HumanRhinosinusitis  IEP associated with Nasal PolypsRGD 
Anxa1RatRhinosinusitis  ISOANXA1 (Homo sapiens)associated with Nasal PolypsRGD 
Anxa1MouseRhinosinusitis  ISOANXA1 (Homo sapiens)associated with Nasal PolypsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa1  (annexin A1)

Genes (Mus musculus)
Anxa1  (annexin A1)

Genes (Homo sapiens)
ANXA1  (annexin A1)


Additional Information