RGD Reference Report - Demonstration of interleukin-1 beta on perifollicular endothelial cells in the thyroid glands of patients with Graves' disease. - Rat Genome Database

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Demonstration of interleukin-1 beta on perifollicular endothelial cells in the thyroid glands of patients with Graves' disease.

Authors: Miyazaki, A  Hanafusa, T  Itoh, N  Miyagawa, J  Kono, N  Tarui, S  Kiyotaki, C  Yoshizaki, K 
Citation: Miyazaki A, etal., J Clin Endocrinol Metab. 1989 Oct;69(4):738-44.
RGD ID: 7401207
Pubmed: PMID:2674184   (View Abstract at PubMed)
DOI: DOI:10.1210/jcem-69-4-738   (Journal Full-text)

We examined the presence of interleukin-1 (IL-1) in the thyroid glands of 20 patients with Graves' disease and 10 control subjects, using anti-IL-1 monoclonal antibodies in conjunction with immunohistochemical techniques. In 13 (65%) Graves' disease patients, IL-1 beta, but not IL-1 alpha, was demonstrated on the capillary endothelial cells (EC) around follicles (perifollicular EC). However, the EC of arteries and veins were negative for both IL-1 beta and IL-1 alpha. In the control group, none of the thyroid glands showed positive staining for IL-1 beta or IL-1 alpha. There was a significant correlation (P less than 0.025) between the presence of IL-1 beta on perifollicular EC and the presence of serum antimicrosomal antibodies. These results provide an important insight into the involvement of IL-1 beta in the development of Graves' disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanGraves' disease  IEP  RGD 
Il1bRatGraves' disease  ISOIL1B (Homo sapiens) RGD 
Il1bMouseGraves' disease  ISOIL1B (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information