RGD Reference Report - Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. - Rat Genome Database

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Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease.

Authors: Higuchi, T  Aiba, Y  Nomura, T  Matsuda, J  Mochida, K  Suzuki, M  Kikutani, H  Honjo, T  Nishioka, K  Tsubata, T 
Citation: Higuchi T, etal., J Immunol. 2002 Jan 1;168(1):9-12.
RGD ID: 7248714
Pubmed: PMID:11751940   (View Abstract at PubMed)

CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice. To assess the role of the ectopic CD40L expression in development of SLE, we have established transgenic mice expressing CD40L on B cells. Some of the 12- to 14-mo-old CD40L-transgenic mice spontaneously produced autoantibodies such as antinuclear Abs, anti-DNA Abs, and antihistone Abs. Moreover, approximately half of the transgenic mice developed glomerulonephritis with immune-complex deposition, whereas the kidneys of the normal littermates showed either no pathological findings or only mild histological changes. These results indicate that CD40L on B cells causes lupus-like disease in the presence of yet unknown environmental factors that by themselves do not induce the disease. Thus, ectopic CD40L expression on B cells may play a crucial role in development of SLE.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD40LGHumanlupus nephritis  ISOCd40lg (Mus musculus) RGD 
Cd40lgRatlupus nephritis  ISOCd40lg (Mus musculus) RGD 
Cd40lgMouselupus nephritis  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40LG  (CD40 ligand)


Additional Information