RGD Reference Report - Interleukin-1 receptor antagonist allele: is it a genetic link between Henoch-Schonlein nephritis and IgA nephropathy? - Rat Genome Database

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Interleukin-1 receptor antagonist allele: is it a genetic link between Henoch-Schonlein nephritis and IgA nephropathy?

Authors: Liu, ZH  Cheng, ZH  Yu, YS  Tang, Z  Li, LS 
Citation: Liu ZH, etal., Kidney Int. 1997 Jun;51(6):1938-42.
RGD ID: 6909151
Pubmed: PMID:9186886   (View Abstract at PubMed)

Henoch-Schonlein purpura nephritis (HSPN) is a multi-organ systemic vasculitis, which shares many clinical, histological and immunological features with IgA nephropathy (IgAN). To address whether these two diseases have a common genetic background, the polymorphism of the variable number tandem repeat (VNTR) of IL-1 receptor antagonist (IL-1ra) gene has been analyzed using PCR in patients diagnosed with HSPN (N = 43) and IgAN (N = 97), together with normal controls (N = 98) and patients with acute post-infectious glomerulonephritis (APGN), under the concept that IL-1 might play an important role in mediating pathogenesis of vasculitis and glomerulonephritis. It was found that the allele frequency and carriage rate of the interleukin-1 receptor antagonist allele (IL1RN*2) of the IL-1ra gene increased significantly in HSPN patients as compared to IgAN (P < 0.01), APGN (P < 0.05) and normal subjects (P < 0.01). Interestingly, varied carriage rates of IL1RN*2 were found among various groups of IgAN patients presenting with different clinical manifestations. The carriage rate of IL1RN*2 was significantly higher in patients with recurrent gross hematuria than other groups of IgAN patients (P < 0.01). Furthermore, although the carriage rate of IL1RN*2 was higher in HSPN (46.5%) than average IgAN patients (26.8%; P < 0.01), there was no significant difference in the carriage rate of IL1RN*2 between HSPN and those IgAN patients with recurrent gross hematuria (42.8%l P > 0.05). It suggested that the IL1RN*2 allele might be a genetic marker shared by HSPN and a special group of IgAN patients with recurrent gross hematuria. Our preliminary observation provided a genetic evidence to support the hypothesis that HSPN and certain subgroup of IgAN are closely related diseases. Such an association of the gene polymorphism of IL-1ra between HSPN and IgAN with recurrent gross hematuria might serve as a key to explore their pathogenesis and eventually a specific intervention.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1RNHumanHenoch-Schoenlein purpura  IAGP DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)RGD 
Il1rnRatHenoch-Schoenlein purpura  ISOIL1RN (Homo sapiens)DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)RGD 
Il1rnMouseHenoch-Schoenlein purpura  ISOIL1RN (Homo sapiens)DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1RNHumanAbnormal renal morphology  IAGP DNA:repeats:intron:IVS2+914_1000dup IL1RN*2RGD 
IL1RNHumanHematuria  IAGP DNA:repeats:intron:IVS2+914_1000dup IL1RN*2RGD 
Objects Annotated

Genes (Rattus norvegicus)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Mus musculus)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Homo sapiens)
IL1RN  (interleukin 1 receptor antagonist)


Additional Information