RGD Reference Report - Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. - Rat Genome Database

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Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis.

Authors: Chuang, PC  Wu, MH  Shoji, Y  Tsai, SJ 
Citation: Chuang PC, etal., J Pathol. 2009 Oct;219(2):232-41.
RGD ID: 6893501
Pubmed: PMID:19606481   (View Abstract at PubMed)
DOI: DOI:10.1002/path.2588   (Journal Full-text)

Endometriosis, defined as the growth of endometrial tissues outside of the uterine cavity, is a severe and complex disease affecting more than 10% of women. The aetiology of endometriosis is unclear but immune dysfunction might be an important factor for its development. The natural function of the immune system is to detect and destroy aberrant or abnormal cells. Failure of the immune system to eradicate these aberrant cells often results in disease pathogenesis. We report here that the phagocytic ability of macrophages is reduced in peritoneal macrophages isolated from women with endometriosis. In-depth investigation revealed that the level of CD36, a class B scavenger receptor, in peritoneal macrophages derived from women with endometriosis was lower than that in normal macrophages. Blockage of CD36 function by neutralized antibody or knocking down CD36 using siRNA impaired the phagocytic ability of normal macrophages. In contrast, forced expression of CD36 in macrophages isolated from women with endometriosis restored phagocytic ability. Taken together, we identified that the scavenger receptor CD36 is reduced in the peritoneal macrophages of women with endometriosis, which leads to a decrease of the phagocytic ability of macrophages. These findings revealed a potential mechanism of immune dysfunction during endometriosis development.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD36Humanendometriosis  IEP mRNA and protein:decreased expression:macrophageRGD 
Cd36Ratendometriosis  ISOCD36 (Homo sapiens)mRNA and protein:decreased expression:macrophageRGD 
Cd36Mouseendometriosis  ISOCD36 (Homo sapiens)mRNA and protein:decreased expression:macrophageRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd36  (CD36 molecule)

Genes (Mus musculus)
Cd36  (CD36 molecule)

Genes (Homo sapiens)
CD36  (CD36 molecule (CD36 blood group))


Additional Information