RGD Reference Report - Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. - Rat Genome Database

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Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.

Authors: Tarakanova, VL  Suarez, F  Tibbetts, SA  Jacoby, MA  Weck, KE  Hess, JL  Speck, SH  Virgin HW, 4TH 
Citation: Tarakanova VL, etal., J Virol. 2005 Dec;79(23):14668-79.
RGD ID: 6483039
Pubmed: PMID:16282467   (View Abstract at PubMed)
PMCID: PMC1287585   (View Article at PubMed Central)
DOI: DOI:10.1128/JVI.79.23.14668-14679.2005   (Journal Full-text)

Human gammaherpesvirus infections are associated with development of lymphoproliferative disease. Understanding of the mechanisms of gammaherpesvirus lymphomagenesis during chronic infection in a natural host has been limited by the exquisite species specificity of human gammaherpesviruses and the expense of primates. Murine gammaherpesvirus gammaHV68 is genetically and biologically related to human gammaherpesviruses and herpesvirus saimiri and has been reported to be associated with lymphoproliferative disease in mice (N. P. Sunil-Chandra, J. Arno, J. Fazakerley, and A. A. Nash, Am. J. Pathol. 145:818-826, 1994). We report the development of an animal model of gammaHV68 lymphomagenesis in BALB/c beta2 microglobulin-deficient mice (BALB beta2m-/-). GammaHV68 infection induced two lymphoproliferative lesions: B-cell lymphoma and atypical lymphoid hyperplasia (ALH). ALH lesion histology resembled lesions of Epstein-Barr virus-associated posttransplant lymphoproliferative disease and was characterized by the abnormal infiltration of the white pulp with cells expressing the plasma cell marker CD138. Lymphomas observed in gammaHV68-infected animals were B220+/CD3- large-cell lymphomas. GammaHV68-infected cells were common in ALH lesions as measured by in situ hybridization with a probe specific for viral tRNAs (vtRNAs), but they were scarce in gammaHV68-infected spleens with normal histology. Unlike ALH lesions, gammaHV68 vtRNA-positive cells were rare in lymphomas. GammaHV68 infection of BALB beta2m-/- mice results in lymphoproliferation and lymphoma, providing a valuable tool for identifying viral and host genes involved in gammaherpesvirus-associated malignancies. Our findings suggest that gammaHV68 induces lymphomas via hit-and-run oncogenesis, paracrine effects, or stimulation of chronic inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lymphoproliferative syndrome  ISOB2m (Mus musculus)6483039; 6483039associated with Herpesviridae InfectionsRGD 
lymphoproliferative syndrome  IMP 6483039associated with Herpesviridae InfectionsRGD 

Objects Annotated

Genes (Rattus norvegicus)
B2m  (beta-2 microglobulin)

Genes (Mus musculus)
B2m  (beta-2 microglobulin)

Genes (Homo sapiens)
B2M  (beta-2-microglobulin)


Additional Information