RGD Reference Report - Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients. - Rat Genome Database

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Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients.

Authors: Giovanni, F  Domenico, P  Alessandro, M  Raffaele, I  Viviana, N  Katia, PA  Paola, BA 
Citation: Giovanni F, etal., J Neuroimmunol. 2011 Dec 15;240-241:137-41. Epub 2011 Oct 15.
RGD ID: 6482817
Pubmed: PMID:22001684   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2011.09.002   (Journal Full-text)

Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS >/=3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PRF1Humanmultiple sclerosis  IEP protein:increased expression:blood and T cellRGD 
Prf1Ratmultiple sclerosis  ISOPRF1 (Homo sapiens)protein:increased expression:blood and T cellRGD 
Prf1Mousemultiple sclerosis  ISOPRF1 (Homo sapiens)protein:increased expression:blood and T cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Prf1  (perforin 1)

Genes (Mus musculus)
Prf1  (perforin 1 (pore forming protein))

Genes (Homo sapiens)
PRF1  (perforin 1)


Additional Information