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Gene: Prf1 (perforin 1 (pore forming protein)) Mus musculus
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Symbol: Prf1
Name: perforin 1 (pore forming protein)
Description: Exhibits calcium ion binding activity and wide pore channel activity. Involved in several processes, including T cell mediated cytotoxicity; defense response to tumor cell; and protein homooligomerization. Localizes to the cytolytic granule; cytoplasmic vesicle; and integral component of membrane. Used to study familial hemophagocytic lymphohistiocytosis 2; multiple sclerosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; 2-tert-butylhydroquinone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytolysin; lymphocyte pore-forming protein; P1; perforin-1; Pfn; Pfp; pore forming protein; Prf-1
Orthologs:
Homo sapiens (human) : PRF1 (perforin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prf1 (perforin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prf1 (perforin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRF1 (perforin 1)
Canis lupus familiaris (dog) : PRF1 (perforin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prf1 (perforin 1)
Sus scrofa (pig) : PRF1 (perforin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381061,297,751 - 61,304,684 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371060,760,584 - 60,767,011 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,693,191 - 60,699,667 (+)NCBImm8
Celera1062,399,002 - 62,405,430 (+)NCBICelera
Cytogenetic Map10 B4NCBI
cM Map1032.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553597
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.