RGD Reference Report - Circadian expression of transcription factor Fra-2 in the rat pineal gland. - Rat Genome Database

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Circadian expression of transcription factor Fra-2 in the rat pineal gland.

Authors: Baler, R  Klein, DC 
Citation: Baler R and Klein DC, J Biol Chem 1995 Nov 10;270(45):27319-25.
RGD ID: 632679
Pubmed: PMID:7592994   (View Abstract at PubMed)

Physiological changes in Fos-like immunoreactivity in the rat pineal gland are shown here to be due primarily to changes in a 42/46-kDa Fos-related antigen (Fra). Studies are presented that indicate this 42/46-kDa Fra is Fra-2, a poorly understood member of the Fos family of transcription factors. Both Fra-2 mRNA and protein are absent during the day and increase robustly at night on a circadian basis; organ culture studies indicate that regulation is mediated by an adrenergic-->cyclic AMP mechanism. AP-1 binding activity changes in parallel to changes in the level of Fra-2 protein.



Objects referenced in this article
Gene Aanat aralkylamine N-acetyltransferase Rattus norvegicus
Gene Fosl2 FOS like 2, AP-1 transcription factor subunit Rattus norvegicus

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