RGD Reference Report - Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

Authors: Clevidence, DE  Overdier, DG  Tao, W  Qian, X  Pani, L  Lai, E  Costa, RH 
Citation: Clevidence DE, etal., Proc Natl Acad Sci U S A 1993 May 1;90(9):3948-52.
RGD ID: 632667
Pubmed: PMID:7683413   (View Abstract at PubMed)
PMCID: PMC46423   (View Article at PubMed Central)

Hepatocyte nuclear factor (HNF)-3 alpha, -3 beta, and -3 gamma are liver transcription factors that mediate the coordinate expression of a number of hepatocyte-specific genes. The HNF-3 proteins share DNA-binding-domain homology among themselves and with the Drosophila homeotic protein forkhead (fkh). The HNF-3/fkh DNA-binding domain constitutes an uncharacterized protein motif that recognizes its cognate DNA binding site as a monomer. Additional HNF-3/fkh-related proteins are known to be required for determination events during embryogenesis in Drosophila and Xenopus. In this report, we describe the isolation of nine additional HNF-3/fkh homologue (HFH) clones from rodent tissue cDNAs by using both low-stringency hybridization and a polymerase chain reaction protocol. Many of the HFH genes exhibit a tissue-restricted expression pattern and are transcribed in tissues other than liver, including brain, kidney, lung, and intestine. The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Foxc2Ratregulation of DNA-templated transcription  TAS  RGD 
Foxd3Ratregulation of DNA-templated transcription  TAS  RGD 

Molecular Function

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Foxc2RatDNA binding  IDA  RGD 
Foxd3RatDNA binding  IDA  RGD 
Foxe3RatDNA-binding transcription factor activity  NAS  RGD 
Foxi2RatDNA-binding transcription factor activity  TAS  RGD 
Foxd3Ratdouble-stranded DNA binding  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Foxc2  (forkhead box C2)
Foxd3  (forkhead box D3)
Foxe3  (forkhead box E3)
Foxi2  (forkhead box I2)

Objects referenced in this article
Gene Foxd1 forkhead box D1 Mus musculus
Gene Foxd2 forkhead box D2 Mus musculus
Gene Foxd3 forkhead box D3 Mus musculus
Gene Foxq1 forkhead box Q1 Mus musculus
Gene Foxd1 forkhead box D1 Rattus norvegicus
Gene Foxd4 forkhead box D4 Rattus norvegicus
Gene Foxq1 forkhead box Q1 Rattus norvegicus

Additional Information