RGD Reference Report - Morphologic and histopathologic change of sodium iodate-induced retinal degeneration in adult rats. - Rat Genome Database

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Morphologic and histopathologic change of sodium iodate-induced retinal degeneration in adult rats.

Authors: Liu, Yang  Li, Ying  Wang, Chenguang  Zhang, Yinan  Su, Guanfang 
Citation: Liu Y, etal., Int J Clin Exp Pathol. 2019 Feb 1;12(2):443-454. eCollection 2019.
RGD ID: 597538544
Pubmed: PMID:31933849   (View Abstract at PubMed)
PMCID: PMC6945090   (View Article at PubMed Central)

Adult teleost fish are capable of regenerating their retinas following injury. In contrast, the adult mammalian retina has little capacity for regeneration. Here, we describe the morphologic and histopathologic course of sodium iodate (NaIO3) injection on rat retinas. A single dose of NaIO3 (50 mg/kg) was administered intravenously to adult Sprague-Dawley male rats. Control animals received sodium chloride. Morphologic and molecular changes following NaIO3 injection were monitored by histological and gene expression analysis. We observed retinal pigment epithelium (RPE) cell death began at 6 h PI. After 3 and 7 days, we found local tissue repair by RPE cell regeneration. This was further confirmed by a significant decrease in photoreceptor cell apoptosis in the outer nuclear layer. Protein-level analysis demonstrated the attenuated regulation of cellular markers specially related to active gliosis in retinal Müller cells, including cellular retinaldehyde-binding protein (CRALBP) and glutamine synthetase (GS), after NaIO3 treatment for 3rd and 7th days. The Müller cells exhibited signs of dedifferentiation, as paired box 6 (PAX6) and SRY box 2 (SOX2) were expressed by NaIO3 stimulated Müller glia proliferation and overexpression of proliferating cell nuclear antigen (PCNA). We concluded that NaIO3 injection can result in significant and progressive damage to RPE and photoreceptor cells. Our observations suggest that Müller cell transient differentiation and RPE recovery is induced in the mammalian retina by relatively high doses of NaIO3. Transient change in Müller cell differentiation and RPE cell recovery may result in photoreceptor apoptosis decrease.




  
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Original Reference(s)
SOX2Humanretinal degeneration  ISOSox2 (Rattus norvegicus)protein:increased expression:retinaRGD 
Sox2Mouseretinal degeneration  ISOSox2 (Rattus norvegicus)protein:increased expression:retinaRGD 
Sox2Ratretinal degeneration  IEP protein:increased expression:retinaRGD 


Genes (Rattus norvegicus)
Sox2  (SRY-box transcription factor 2)

Genes (Mus musculus)
Sox2  (SRY (sex determining region Y)-box 2)

Genes (Homo sapiens)
SOX2  (SRY-box transcription factor 2)