RGD Reference Report - Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes. - Rat Genome Database

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Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.

Authors: Fava, C  Montagnana, M  Danese, E  Almgren, P  Hedblad, B  Engstrom, G  Berglund, G  Minuz, P  Melander, O 
Citation: Fava C, etal., Pharmacogenet Genomics. 2010 Feb;20(2):94-103.
RGD ID: 5688727
Pubmed: PMID:20065888   (View Abstract at PubMed)
DOI: DOI:10.1097/FPC.0b013e3283349ec9   (Journal Full-text)

OBJECTIVES: The soluble epoxide hydrolase (gene name EPHX2) is responsible for metabolism of 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies. The aim of this study was to evaluate the effect of four polymorphisms in the EPHX2 gene on blood pressure levels, hypertension prevalence, and risk of incident cardiovascular events in a large sample of middle-aged Swedes. METHODS: The incidence of cardiovascular events (coronary events, n = 274; ischemic stroke, n = 197) was monitored over 10 years of follow-up. RESULTS: In the whole population, all polymorphisms had no effect on the studied parameters but a positive interaction between male sex and three SNPs including the K55R was evident: male, but not female, EPHX2 R55R homozygotes had significantly higher crude and adjusted systolic blood pressure and higher hypertension prevalence with respect to K-carriers. Kaplan-Meier curves showed higher incidence of ischemic strokes in male R55R homozygotes with respect to K-carriers (P = 0.015 by log-rank test). After adjustment for major cardiovascular risk factors, the hazard ratio for incident ischemic stroke in male R55R homozygotes remained significantly higher (hazard ratio: 4.8; 95% confidence interval: 1.2-19.9). CONCLUSION: The functional K55R polymorphism of the EPHX2 gene confers a higher risk of hypertension prevalence and increases the risk of incident ischemic stroke in male homozygotes. Additional studies are needed to confirm these data and to elucidate the interaction between sex and the EPHX2 K55R polymorphism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EPHX2Humanhypertension susceptibilityIAGP DNA:missense mutation:cds:p.K55R (human)RGD 
Ephx2Rathypertension susceptibilityISOEPHX2 (Homo sapiens)DNA:missense mutation:cds:p.K55R (human)RGD 
Ephx2Mousehypertension susceptibilityISOEPHX2 (Homo sapiens)DNA:missense mutation:cds:p.K55R (human)RGD 
EPHX2HumanStroke susceptibilityIAGP DNA:missense mutation:cds:p.K55R (human)RGD 
Ephx2RatStroke susceptibilityISOEPHX2 (Homo sapiens)DNA:missense mutation:cds:p.K55R (human)RGD 
Ephx2MouseStroke susceptibilityISOEPHX2 (Homo sapiens)DNA:missense mutation:cds:p.K55R (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EPHX2HumanIschemic stroke susceptibilityIAGP DNA:missense mutation:cds:p.K55RRGD 
Objects Annotated

Genes (Rattus norvegicus)
Ephx2  (epoxide hydrolase 2)

Genes (Mus musculus)
Ephx2  (epoxide hydrolase 2, cytoplasmic)

Genes (Homo sapiens)
EPHX2  (epoxide hydrolase 2)


Additional Information