RGD Reference Report - Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke.

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Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke.
Authors:	Beer, C Blacker, D Bynevelt, M Hankey, GJ Puddey, IB
Citation:	Beer C, etal., J Neuroinflammation. 2010 Oct 29;7:71.
RGD ID:	5508779
Pubmed:	PMID:21034449 (View Abstract at PubMed)
PMCID:	PMC2984413 (View Article at PubMed Central)
DOI:	DOI:10.1186/1742-2094-7-71 (Journal Full-text)
BACKGROUND: Vascular dysfunction and brain inflammation are thought to contribute to the pathophysiology of cerebral injury in acute stroke. However acute inflammation and vascular dysfunction may simply be markers of an acute phase response to cerebral injury, reflecting the size of the cerebral lesion. We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke. METHODS: Fifty-seven men and women recruited within 96 hours of acute ischaemic stroke at two tertiary hospitals participated in this cross sectional observational study. Clinical, imaging (stroke lesions area measured with perfusion CT) and laboratory data were the independent variables and co-variates. The outcome variable was serum S100B concentration, analysed by multivariate regression. RESULTS: High sensitivity-CRP (B = 0.41) and lesion area (B = 0.69) were independently associated with S100B concentration (R2 = 0.75, p < 0.01). Other variables with significant univariate associations with S100B concentration were not independently associated with S100B concentration in the final multivariate model. CONCLUSION: The degree of systemic inflammation is associated with S100B concentration in acute ischaemic stroke, independent of the size of the ischaemic lesion.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
S100B	Human	Inflammation		IEP		associated with Stroke	RGD
S100b	Rat	Inflammation		ISO	S100B (Homo sapiens)	associated with Stroke	RGD
S100b	Mouse	Inflammation		ISO	S100B (Homo sapiens)	associated with Stroke	RGD

Objects Annotated

Genes (Rattus norvegicus)

S100b (S100 calcium binding protein B)

Genes (Mus musculus)

S100b (S100 protein, beta polypeptide, neural)

Genes (Homo sapiens)

S100B (S100 calcium binding protein B)

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Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke.