RGD Reference Report - A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. - Rat Genome Database

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A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide.

Authors: Kunugi, H  Hashimoto, R  Yoshida, M  Tatsumi, M  Kamijima, K 
Citation: Kunugi H, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):44-6.
RGD ID: 5508376
Pubmed: PMID:15274039   (View Abstract at PubMed)
DOI: DOI:10.1002/ajmg.b.30062   (Journal Full-text)

Several lines of evidence have implicated that neurotrophins play an important role in the pathophysiology of mood disorders. This study examined whether a common missense polymorphism (S205L) of a gene encoding the p75NTR, the low-affinity receptor for neurotrophins, is associated with depressive disorder in a Japanese sample of 164 patients and the same number of controls matched for age and sex. There were significant differences in the genotype distribution and allele frequency between the cases and controls. The minor allele (L205) was significantly decreased in the patients than in the controls (P < 0.05, odds ratio 0.54, 95% CI 0.31-0.94), suggesting that this allele may have a protective effect against the development of major depression. Furthermore, this association was more strongly observed in the patients with a history of attempted suicide than those without such a history. Our results suggest that the S205L polymorphism of the p75NTR gene is involved in the pathogenesis of depressive disorder and suicidal behavior.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGFRHumandepressive disorder  IAGP DNA:SNP:CDS:p.S205L and minor (L) allele appears protectiveRGD 
NgfrRatdepressive disorder  ISONGFR (Homo sapiens)DNA:SNP:CDS:p.S205L and minor (L) allele appears protective (human)RGD 
NgfrMousedepressive disorder  ISONGFR (Homo sapiens)DNA:SNP:CDS:p.S205L and minor (L) allele appears protective (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)


Additional Information