RGD Reference Report - From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. - Rat Genome Database

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From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis.

Authors: Lincecum, JM  Vieira, FG  Wang, MZ  Thompson, K  De Zutter, GS  Kidd, J  Moreno, A  Sanchez, R  Carrion, IJ  Levine, BA  Al-Nakhala, BM  Sullivan, SM  Gill, A  Perrin, S 
Citation: Lincecum JM, etal., Nat Genet. 2010 May;42(5):392-9. Epub 2010 Mar 28.
RGD ID: 5490547
Pubmed: PMID:20348957   (View Abstract at PubMed)
DOI: DOI:10.1038/ng.557   (Journal Full-text)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Using unbiased transcript profiling in an ALS mouse model, we identified a role for the co-stimulatory pathway, a key regulator of immune responses. Furthermore, we observed that this pathway is upregulated in the blood of 56% of human patients with ALS. A therapy using a monoclonal antibody to CD40L was developed that slows weight loss, delays paralysis and extends survival in an ALS mouse model. This work demonstrates that unbiased transcript profiling can identify cellular pathways responsive to therapeutic intervention in a preclinical model of human disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD40LGHumanamyotrophic lateral sclerosis  ISOCd40lg (Mus musculus) RGD 
Cd40lgRatamyotrophic lateral sclerosis  ISOCd40lg (Mus musculus) RGD 
Cd40lgMouseamyotrophic lateral sclerosis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40LG  (CD40 ligand)


Additional Information