RGD Reference Report - FC gamma RIIa polymorphism in patients with rheumatoid arthritis. - Rat Genome Database

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FC gamma RIIa polymorphism in patients with rheumatoid arthritis.

Authors: Pawlik, A  Ostanek, L  Brzosko, I  Brzosko, M  Fabrycy, IF  Florczak, M  Szklarz, BG 
Citation: Pawlik A, etal., Clin Exp Rheumatol. 2002 Nov-Dec;20(6):841-4.
RGD ID: 5147978
Pubmed: PMID:12508778   (View Abstract at PubMed)

OBJECTIVE: Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2. METHODS: Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers. RESULTS: No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype. CONCLUSION: The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanrheumatoid arthritis  IAGP DNA:polymorphism: :p.H131R (human)RGD 
Fcgr2aRatrheumatoid arthritis  ISOFCGR2A (Homo sapiens)DNA:polymorphism: :p.H131R (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information