RGD Reference Report - Interleukin-20 targets renal cells and is associated with chronic kidney disease. - Rat Genome Database

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Interleukin-20 targets renal cells and is associated with chronic kidney disease.

Authors: Wei, CC  Li, HH  Hsu, YH  Hsing, CH  Sung, JM  Chang, MS 
Citation: Wei CC, etal., Biochem Biophys Res Commun. 2008 Sep 26;374(3):448-53. Epub 2008 Jul 17.
RGD ID: 5147394
Pubmed: PMID:18639518   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2008.07.039   (Journal Full-text)

Interleukin (IL)-10 is an anti-inflammatory factor that suppresses renal fibrosis and improves renal function in CKD rats. IL-20 belongs to the IL-10 family; therefore, we sought to determine whether IL-20 is involved in CKD. CKD patients at stage five expressed significantly higher IL-20 in serum than controls. Immunohistochemical staining demonstrated that more IL-20 protein was expressed in the kidney tubular-epithelial cells, mesangial cells, and immune cells of CKD rats with a 5/6 nephrectomy. The lung, liver, and heart tissue of CKD rats also overexpressed IL-20. Thus, we treated two tubular epithelial cells, TKPTS and M-1 cells, with IL-20 to study its effects on CKD. IL-20 treatment induced apoptosis in these cells via caspase-3 activation. Incubating IL-20 with rat interstitial fibroblasts, NRK-49F cells, upregulated TGF-beta1 production, one key inducer for renal fibrogenesis. Therefore, IL-20 injured renal epithelial cells and induced fibroblasts to produce TGF-beta1 that hastened the progression of CKD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
end stage renal disease  IEP 5147394protein:increased expression:serumRGD 
end stage renal disease  IEP 5147394protein:increased expression:multiple organsRGD 
end stage renal disease  ISOIl20 (Rattus norvegicus) and IL20 (Homo sapiens)5147394protein:increased expression:multiple organsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il20  (interleukin 20)

Genes (Mus musculus)
Il20  (interleukin 20)

Genes (Homo sapiens)
IL20  (interleukin 20)


Additional Information