RGD Reference Report - Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. - Rat Genome Database

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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Authors: Walker, JK  Ahumada, A  Frank, B  Gaspard, R  Berman, K  Quackenbush, J  Schwartz, DA 
Citation: Walker JK, etal., Am J Respir Cell Mol Biol. 2006 Jun;34(6):711-8. Epub 2006 Feb 10.
RGD ID: 4892093
Pubmed: PMID:16474097   (View Abstract at PubMed)
PMCID: PMC2644233   (View Article at PubMed Central)
DOI: DOI:10.1165/rcmb.2005-0314OC   (Journal Full-text)

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CCR5Humanasthma  ISOCcr5 (Mus musculus) RGD 
Ccr5Ratasthma  ISOCcr5 (Mus musculus) RGD 
Ccr5Mouseasthma  IMP  RGD 


Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)