RGD Reference Report - Chemokine-receptor upregulation and disease severity in respiratory syncytial virus infection. - Rat Genome Database

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Chemokine-receptor upregulation and disease severity in respiratory syncytial virus infection.

Authors: Morrison, PT  Sharland, M  Thomas, LH  Manna, S  Handforth, J  Tibby, S  Friedland, JS 
Citation: Morrison PT, etal., Clin Immunol. 2008 Jul;128(1):85-93. Epub 2008 Apr 25.
RGD ID: 4892079
Pubmed: PMID:18439876   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clim.2008.03.460   (Journal Full-text)

Respiratory Syncytial Virus (RSV) infection is an important cause of severe infant bronchiolitis, partly due to lower airway inflammation orchestrated by virus-induced chemokine secretion. Chemokine receptors may therefore be therapeutic targets. We investigated RSV-induced chemokine receptor (CCR) 1, 2 and 5 surface expressions in a cellular model and in infants. RSV infection increased human monocytic CCR1, 2 and 5 expression, as assessed by FACS, via replication-dependent mechanisms. CCR1 and CCR5 levels peaked at 36 h and CCR2 levels at 48 h. Monocytes from infants with RSV-bronchiolitis significantly increased CCR1 expression after ex vivo RSV infection compared to controls. Expression of CCR5 also increased, and correlated with CCR1 expression (r=0.78, p<0.0001). CCR1 upregulation correlated with disease severity markers. Monocyte CCR1 receptors were functionally active as stimulation resulted in calcium influx. CCR1/5 blocking strategies may be useful in decreasing cellular inflammation in RSV infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR5Humanrespiratory syncytial virus infectious disease  IEP protein:increased expression:blood and monocyte (human)RGD 
Ccr5Ratrespiratory syncytial virus infectious disease  ISOCCR5 (Homo sapiens)protein:increased expression:blood and monocyte (human)RGD 
Ccr5Mouserespiratory syncytial virus infectious disease  ISOCCR5 (Homo sapiens)protein:increased expression:blood and monocyte (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information