RGD Reference Report - Chemokine receptor 5 big up tri, open32 allele in patients with severe pandemic (H1N1) 2009. - Rat Genome Database

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Chemokine receptor 5 big up tri, open32 allele in patients with severe pandemic (H1N1) 2009.

Authors: Keynan, Y  Juno, J  Meyers, A  Ball, TB  Kumar, A  Rubinstein, E  Fowke, KR 
Citation: Keynan Y, etal., Emerg Infect Dis. 2010 Oct;16(10):1621-2.
RGD ID: 4892063
Pubmed: PMID:20875295   (View Abstract at PubMed)
PMCID: PMC3294998   (View Article at PubMed Central)
DOI: DOI:10.3201/eid1610.100108   (Journal Full-text)

Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Delta32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Delta32 allele among white patients with severe disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR5HumanHuman Influenza severityIAGP DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)RGD 
Ccr5RatHuman Influenza severityISOCCR5 (Homo sapiens)DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)RGD 
Ccr5MouseHuman Influenza severityISOCCR5 (Homo sapiens)DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information