RGD Reference Report - Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia. - Rat Genome Database

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Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia.

Authors: Miyazaki, E  Nureki, S  Fukami, T  Shigenaga, T  Ando, M  Ito, K  Ando, H  Sugisaki, K  Kumamoto, T  Tsuda, T 
Citation: Miyazaki E, etal., Am J Respir Crit Care Med. 2002 Apr 15;165(8):1125-31.
RGD ID: 4145602
Pubmed: PMID:11956056   (View Abstract at PubMed)
DOI: DOI:10.1164/ajrccm.165.8.2106110   (Journal Full-text)

Thymus- and activation-regulated chemokine (TARC/CCL17) is a lymphocyte-directed CC chemokine, which plays a role in the recruitment of CC chemokine receptor-4 positive T helper 2 (Th2) cells. In this study, we measured concentrations of TARC and Th2 cell-derived cytokines in bronchoalveolar lavage (BAL) fluid, as well as TARC concentrations in serum from patients with eosinophilic pneumonia and other interstitial lung diseases. TARC was significantly elevated in BAL fluids from patients with eosinophilic pneumonia (median, 240 pg/ml), whereas TARC was undetectable (< 7 pg/ml) in most cases of hypersensitivity pneumonitis, sarcoidosis, and idiopathic pulmonary fibrosis, as well as in healthy control subjects. Also, when present, quantities were less than 20 pg/ml. Elevated concentrations of interleukin (IL)-4, IL-5, and IL-13 were also detected in BAL fluid from patients with eosinophilic pneumonia. Interestingly, TARC concentrations in BAL fluids were closely correlated with the concentrations of IL-5 and IL-13. A serial examination showed that elevated TARC in BAL fluid rapidly fell to below detectable limits preceding decreases in IL-5 concentration and eosinophil percentage. Our results, in concordance with previous studies, demonstrate the potential activity of TARC for recruiting Th2 cells to the lungs and suggest a significant role for TARC in the pathogenesis of eosinophilic pneumonia.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CCL17Humanpulmonary eosinophilia  IEP protein:increased expression:respiratory system fluid/secretionRGD 
Ccl17Ratpulmonary eosinophilia  ISORGD:1349365protein:increased expression:respiratory system fluid/secretionRGD 
Ccl17Mousepulmonary eosinophilia  ISORGD:1349365protein:increased expression:respiratory system fluid/secretionRGD 


Genes (Rattus norvegicus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Mus musculus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Homo sapiens)
CCL17  (C-C motif chemokine ligand 17)