RGD Reference Report - Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis. - Rat Genome Database

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Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis.

Authors: Aparisi, L  Farre, A  Gomez-Cambronero, L  Martinez, J  De Las Heras, G  Corts, J  Navarro, S  Mora, J  Lopez-Hoyos, M  Sabater, L  Ferrandez, A  Bautista, D  Perez-Mateo, M  Mery, S  Sastre, J 
Citation: Aparisi L, etal., Gut. 2005 May;54(5):703-9. doi: 10.1136/gut.2004.047142.
RGD ID: 408425973
Pubmed: PMID:15831920   (View Abstract at PubMed)
PMCID: PMC1774474   (View Article at PubMed Central)
DOI: DOI:10.1136/gut.2004.047142   (Journal Full-text)


BACKGROUND: Increased serum antibodies against carbonic anhydrase II (CA-II Ab) or IgG4 levels have been reported in cases of autoimmune chronic pancreatitis (ACP).
AIM: To assess the relevance of serum CA-II Ab and IgG4 levels for the diagnosis of ACP in idiopathic CP (ICP) versus alcoholic CP and Sjogren's syndrome (SS).
SUBJECTS: This was a multicentre study involving 227 subjects divided into four groups: ICP (n = 54), normal controls (n = 54, paired by age and sex with ICP patients), alcoholic CP (n = 86), and SS (n = 33).
METHODS: CA-II Ab was measured by ELISA and confirmed by western blotting. A score of easy clinical use with major clinical, morphological, and biochemical parameters for the diagnosis of ACP was applied.
RESULTS: The percentage of patients with increased serum CA-II Ab was higher in the ICP group (28%) than in controls (1.9%) and in patients with alcoholic CP (10.5%), but lower than in patients with SS (64%). The proportion with elevated IgG4 levels was higher in the ICP group (15%) compared with controls (1.9%) and SS (0%) but not significantly different from alcoholic CP (8%). Most ICP patients (7/8) with high IgG4 levels exhibited increased CA-II Ab and a compatible ACP score. A definitive diagnosis of ACP by histological analysis was associated with other autoimmune disorders, an increase in both serum IgG4 and CA-II Ab levels, and IgG4 positive plasma cells.
CONCLUSIONS: The increase in serum IgG4 levels was strongly associated with elevated CA-II Ab levels, manifestations compatible with ACP, and lymphoplasmacytic infiltration when surgical specimens were available.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Car2  (carbonic anhydrase 2)

Genes (Mus musculus)
Car2  (carbonic anhydrase 2)

Genes (Homo sapiens)
CA2  (carbonic anhydrase 2)


Additional Information