RGD Reference Report - Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain. - Rat Genome Database

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Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain.

Authors: Olling, J D  Ulrichsen, J  Christensen, D Z  Woldbye, D P D 
Citation: Olling JD, etal., J Neurosci Res. 2009 Aug 1;87(10):2386-97. doi: 10.1002/jnr.22049.
RGD ID: 405096484
Pubmed: PMID:19267419   (View Abstract at PubMed)
DOI: DOI:10.1002/jnr.22049   (Journal Full-text)

Previous studies show that chronic ethanol treatment induces prominent changes in brain neuropeptide Y (NPY). The purpose of the present study was to explore ethanol effects at a deeper NPY-system level, measuring expression of NPY and its receptors (Y1, Y2, Y5) as well as NPY receptor binding and NPY-stimulated [(35)S]GTPgammaS functional binding. Rats received intragastric ethanol repeatedly for 4 days, and the NPY system was studied in the hippocampal dentate gyrus (DG), CA3, CA1, and piriform cortex (PirCx) and neocortex (NeoCx) during intoxication, peak withdrawal (16 hr), late withdrawal (3 days), and 1 week after last ethanol administration. NPY mRNA levels decreased during intoxication and at 16 hr in hippocampal regions but increased in the PirCx and NeoCx at 16 hr. NPY mRNA levels were increased at 3 days and returned to control levels in most regions at 1 week. Substantial changes also occurred at the receptor level. Thus Y1, Y2, and Y5 mRNA labelling decreased at 16 hr in most regions, returning to control levels at 3 days, except for PirCx Y2 mRNA, which increased at 3 days and 1 week. Conversely, increases in NPY receptor binding occurred in hippocampal regions during intoxication and in functional binding in the DG and NeoCx during intoxication and at 16 hr and in PirCx during intoxication and at 1 week. Thus this study shows that ethanol intoxication and withdrawal induce complex plastic changes in the NPY system, with decreased/increased gene expression or binding occurring in a time- and region-specific manner. These changes may play an important role in mediating ethanol-induced changes in neuronal excitability.



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NPY1RHumanethanol decreases expression ISONpy1r (Rattus norvegicus)Ethanol decreases expression of Npy1r mRNA in hippocampus more ...RGD 
Npy1rRatethanol decreases expression EXP Ethanol decreases expression of Npy1r mRNA in hippocampus more ...RGD 
Npy1rMouseethanol decreases expression ISONpy1r (Rattus norvegicus)Ethanol decreases expression of Npy1r mRNA in hippocampus more ...RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Npy1rRatresponse to ethanol  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Npy1r  (neuropeptide Y receptor Y1)

Genes (Mus musculus)
Npy1r  (neuropeptide Y receptor Y1)

Genes (Homo sapiens)
NPY1R  (neuropeptide Y receptor Y1)


Additional Information