RGD Reference Report - Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza. - Rat Genome Database

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Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza.

Authors: Kawada, Jun-ichi  Kimura, Hiroshi  Kamachi, Yoshiro  Nishikawa, Kazuo  Taniguchi, Mariko  Nagaoka, Kayuri  Kurahashi, Hiroki  Kojima, Seiji  Morishima, Tsuneo 
Citation: Kawada J, etal., J Gen Virol. 2006 Jun;87(Pt 6):1677-83. doi: 10.1099/vir.0.81670-0.
RGD ID: 39456106
Pubmed: PMID:16690933   (View Abstract at PubMed)
DOI: DOI:10.1099/vir.0.81670-0   (Journal Full-text)

In order to clarify the mechanism of the host response to influenza virus, gene-expression profiles of peripheral blood obtained from paediatric patients with influenza were investigated by oligonucleotide microarray. In the acute phase of influenza, 200 genes were upregulated and 20 genes were downregulated compared with their expression in the convalescent phase. Interferon-regulated genes, such as interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) and vipirin, were strongly upregulated in the acute phase. Gene ontology analysis showed that immune response genes were highly overrepresented among the upregulated genes. Gene-expression profiles of influenza patients with and without febrile convulsion were also studied. In patients with febrile convulsion, 22 genes were upregulated and five were downregulated compared with their expression in patients without febrile convulsion. These results should help to clarify the pathogenesis of influenza and its neurological complications.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NRG1HumanFebrile Seizures  HEP associated with influenza and mRNA:increased expression:blood (human)RGD 
Nrg1RatFebrile Seizures  ISONRG1 (Homo sapiens)associated with influenza and mRNA:increased expression:blood (human)RGD 
Nrg1MouseFebrile Seizures  ISONRG1 (Homo sapiens)associated with influenza and mRNA:increased expression:blood (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nrg1  (neuregulin 1)

Genes (Mus musculus)
Nrg1  (neuregulin 1)

Genes (Homo sapiens)
NRG1  (neuregulin 1)


Additional Information