RGD Reference Report - Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. - Rat Genome Database

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Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure.

Authors: Wei, Chaoliang  Qiu, Jinsong  Zhou, Yu  Xue, Yuanchao  Hu, Jing  Ouyang, Kunfu  Banerjee, Indroneal  Zhang, Caimei  Chen, Biyi  Li, Hairi  Chen, Ju  Song, Long-Sheng  Fu, Xiang-Dong 
Citation: Wei C, etal., Cell Rep. 2015 Mar 10;10(9):1521-1533. doi: 10.1016/j.celrep.2015.02.013. Epub 2015 Mar 5.
RGD ID: 329845877
Pubmed: PMID:25753418   (View Abstract at PubMed)
PMCID: PMC4559494   (View Article at PubMed Central)
DOI: DOI:10.1016/j.celrep.2015.02.013   (Journal Full-text)

Heart failure is characterized by the transition from an initial compensatory response to decompensation, which can be partially mimicked by transverse aortic constriction (TAC) in rodent models. Numerous signaling molecules have been shown to be part of the compensatory program, but relatively little is known about the transition to decompensation that leads to heart failure. Here, we show that TAC potently decreases the RBFox2 protein in the mouse heart, and cardiac ablation of this critical splicing regulator generates many phenotypes resembling those associated with decompensation in the failing heart. Global analysis reveals that RBFox2 regulates splicing of many genes implicated in heart function and disease. A subset of these genes undergoes developmental regulation during postnatal heart remodeling, which is reversed in TAC-treated and RBFox2 knockout mice. These findings suggest that RBFox2 may be a critical stress sensor during pressure overload-induced heart failure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RBFOX2Humancongestive heart failure  ISORbfox2 (Mus musculus)protein:decreased expression:heart (mouse)RGD 
Rbfox2Ratcongestive heart failure  ISORbfox2 (Mus musculus)protein:decreased expression:heart (mouse)RGD 
Rbfox2Mousecongestive heart failure  IEP protein:decreased expression:heart (mouse)RGD 
RBFOX2Humandilated cardiomyopathy  ISORbfox2 (Mus musculus) RGD 
Rbfox2Ratdilated cardiomyopathy  ISORbfox2 (Mus musculus) RGD 
Rbfox2Mousedilated cardiomyopathy  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rbfox2  (RNA binding fox-1 homolog 2)

Genes (Mus musculus)
Rbfox2  (RNA binding protein, fox-1 homolog (C. elegans) 2)

Genes (Homo sapiens)
RBFOX2  (RNA binding fox-1 homolog 2)


Additional Information