RGD Reference Report - Serum levels of Interleukins 1-Alpha & 12 as Predictors of Disease Progression in Hepatitis C Diabetic Patients. - Rat Genome Database

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Serum levels of Interleukins 1-Alpha & 12 as Predictors of Disease Progression in Hepatitis C Diabetic Patients.

Authors: Khalil, Mohammed  El-Badawy, Omnia  Sharaf-Eldin, Abeer  Sadek, Ahmed  Sabry, Ayman 
Citation: Khalil M, etal., Egypt J Immunol. 2018 Jan;25(1):181-190.
RGD ID: 25440502
Pubmed: PMID:30243010   (View Abstract at PubMed)

This study evaluates the usefulness of interleukins 1 alpha and 12 in predicting disease progression in diabetic HCV and HCV related liver diseases compared to non-diabetics. The study included 76 hepatitis C virus-infected patients [38 diabetics, 38 none (with, without cirrhosis)]. Serum levels of IL-1α and IL-12 were measured by ELISA. Serum levels of IL-1α and IL12 were higher in cirrhotic than non -cirrhotic patients and higher in the diabetic patients. Significant correlations were detected between IL-1α, prothrombin time (PT), and severity scores in cirrhotic patients. Levels of both cytokines correlated with the fasting plasma glucose levels. Stronger correlations were evident between IL-12, PT and total bilirubin than IL-1α in diabetics. In conclusion; IL-1α and IL-12 are good markers for monitoring liver disease progression in cirrhotic and diabetic HCV patients. Whereas IL-1α is a better marker in cirrhotic patients, IL-12 is somewhat superior to IL-1α in diabetic patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL12AHumanhepatitis C disease_progressionIEP associated with diabetes mellitusRGD 
Il12aRathepatitis C disease_progressionISOIL12A (Homo sapiens)associated with diabetes mellitusRGD 
Il12aMousehepatitis C disease_progressionISOIL12A (Homo sapiens)associated with diabetes mellitusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il12a  (interleukin 12A)

Genes (Mus musculus)
Il12a  (interleukin 12a)

Genes (Homo sapiens)
IL12A  (interleukin 12A)


Additional Information