RGD Reference Report - Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. - Rat Genome Database

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Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis.

Authors: Hegardt, FG 
Citation: Hegardt FG Biochimie. 1998 Oct;80(10):803-6.
RGD ID: 2326134
Pubmed: PMID:9893938   (View Abstract at PubMed)

Mitochondrial and cytosolic HMG-CoA synthases are encoded by two different genes. Control of ketogenesis is exerted by transcriptional regulation of mitochondrial HMG-CoA synthase. Fasting, cAMP, and fatty acids increase its transcriptional rate, while refeeding and insulin repress it. Fatty acids increase transcription through peroxisomal proliferator regulatory element (PPRE), to which peroxisome proliferator activated receptor (PPAR) can bind. Other transcription factors such as chicken ovalbumin upstream promoter transcription factor (COUP-TF) and hepatocyte nuclear factor 4 (HNF-4) compete for the PPRE site, modulating the response of PPAR.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Hmgcs1  (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Hmgcs2  (3-hydroxy-3-methylglutaryl-CoA synthase 2)

Genes (Mus musculus)
Hmgcs1  (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1)
Hmgcs2  (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2)

Genes (Homo sapiens)
HMGCS1  (3-hydroxy-3-methylglutaryl-CoA synthase 1)
HMGCS2  (3-hydroxy-3-methylglutaryl-CoA synthase 2)


Additional Information