RGD Reference Report - Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients.

Authors: Simo, R  Higuera, M  Garcia-Ramirez, M  Canals, F  Garcia-Arumi, J  Hernandez, C 
Citation: Simo R, etal., Arch Ophthalmol. 2008 Aug;126(8):1076-81.
RGD ID: 2313982
Pubmed: PMID:18695102   (View Abstract at PubMed)
DOI: DOI:10.1001/archopht.126.8.1076   (Journal Full-text)

OBJECTIVES: To determine levels of apolipoprotein (apo) A-I and apo H in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and to examine whether apo A-I and apo H messenger RNA (mRNA) levels are overexpressed in the diabetic retina. METHODS: Vitreous samples from 4 diabetic patients with PDR and 8 nondiabetic patients with macular hole were selected for proteomic analysis. Fourteen additional samples (7 from patients with PDR and 7 from patients with macular hole) were used for Western blot analysis. Fourteen postmortem eyes (7 from diabetic and 7 from nondiabetic donors) were used to perform quantitative real-time polymerase chain reaction analysis. RESULTS: Intravitreous apo A-I and apo H levels were significantly higher in patients with PDR than in the control group. The apo A-I and apo H mRNA levels obtained from the retinas of diabetic donors were significantly higher than those obtained from nondiabetic donors. Retinal pigment epithelium was the main contributor to the differences. CONCLUSIONS: Levels of apo A-I and apo H are elevated in the vitreous fluid of diabetic patients with PDR. In addition, we provide the first evidence, to our knowledge, that a higher expression of apo A-I and apo H mRNAs exists in the diabetic retina. CLINICAL RELEVANCE: The results of this study may be relevant to new treatment strategies aimed toward reducing the development of diabetic retinopathy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOHHumandiabetes mellitus  IEP mRNA:increased expression:retinaRGD 
ApohRatdiabetes mellitus  ISOAPOH (Homo sapiens)mRNA:increased expression:retinaRGD 
ApohMousediabetes mellitus  ISOAPOH (Homo sapiens)mRNA:increased expression:retinaRGD 
APOHHumandiabetic retinopathy  IEP protein:increased expression:vitreous humorRGD 
ApohRatdiabetic retinopathy  ISOAPOH (Homo sapiens)protein:increased expression:vitreous humorRGD 
ApohMousediabetic retinopathy  ISOAPOH (Homo sapiens)protein:increased expression:vitreous humorRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoh  (apolipoprotein H)

Genes (Mus musculus)
Apoh  (apolipoprotein H)

Genes (Homo sapiens)
APOH  (apolipoprotein H)


Additional Information