RGD Reference Report - Impaired Synthesis of Erythropoietin, Glutamine Synthetase and Metallothionein in the Skin of NOD/SCID/gamma (c) (null) and Foxn1 nu/nu Mice with Misbalanced Production of MHC Class II Complex.

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Impaired Synthesis of Erythropoietin, Glutamine Synthetase and Metallothionein in the Skin of NOD/SCID/gamma (c) (null) and Foxn1 nu/nu Mice with Misbalanced Production of MHC Class II Complex.
Authors:	Danielyan, L Verleysdonk, S Buadze, M Gleiter, CH Buniatian, GH
Citation:	Danielyan L, etal., Neurochem Res. 2009 Oct 14.
RGD ID:	2313831
Pubmed:	PMID:19826948 (View Abstract at PubMed)
DOI:	DOI:10.1007/s11064-009-0074-x (Journal Full-text)
Most skin pathologies are characterized by unbalanced synthesis of major histocompatability complex II (MHC-II) proteins. Healthy skin keratinocytes simultaneously produce large amounts of MHC-II and regeneration-supporting proteins, e.g. erythropoietin (EPO), EPO receptor (EPOR), glutamine synthetase (GS) and metallothionein (MT). To investigate the level of regeneration-supporting proteins in the skin during misbalanced production of MHC-II, skin sections from nonobese diabetic/severe combined immunodeficient (NOD/SCID)/gamma (c) (null) and or Foxn1 nu/nu mice which are a priory known to under- and over-express MHC II, respectively, were used. Double immunofluorescence analysis of NOD/SCID/gamma (c) (null) skin sections showed striking decrease in expression of MHC-II, EPO, GS and MT. In Foxn1 nu/nu mouse skin, GS was strongly expressed in epidermis and in hair follicles (HF), which lacked EPO. In nude mouse skin EPO and MHC-II were over-expressed in dermal fibroblasts and they were completely absent from cortex, channel, medulla and keratinocytes surrounding the HF, suggest a role for EPO in health and pathology of hair follicle. The level of expression of EPO and GS in both mutant mice was confirmed by results of Western blot analyses. Strong immunoresponsiveness of EPOR in the hair channels of NOD/SCID/gamma (c) (null) mouse skin suggests increased requirements of skin cells for EPO and possible benefits of exogenous EPO application during disorders of immune system accompanied by loss MHC-II in skin cells.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
EPO	Human	severe combined immunodeficiency		ISO	Epo (Mus musculus)	Protein: decreased expression:skin	RGD
Epo	Rat	severe combined immunodeficiency		ISO	Epo (Mus musculus)	Protein: decreased expression:skin	RGD
Epo	Mouse	severe combined immunodeficiency		IMP		Protein: decreased expression:skin	RGD

Objects Annotated

Genes (Rattus norvegicus)

Epo (erythropoietin)

Genes (Mus musculus)

Epo (erythropoietin)

Genes (Homo sapiens)

EPO (erythropoietin)

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Impaired Synthesis of Erythropoietin, Glutamine Synthetase and Metallothionein in the Skin of NOD/SCID/gamma (c) (null) and Foxn1 nu/nu Mice with Misbalanced Production of MHC Class II Complex.