RGD Reference Report - Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions. - Rat Genome Database

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Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions.

Authors: Postler, E  Rimner, A  Beschorner, R  Schluesener, HJ  Meyermann, R 
Citation: Postler E, etal., J Neuroimmunol. 2000 Apr 3;104(1):85-91.
RGD ID: 2313026
Pubmed: PMID:10683518   (View Abstract at PubMed)

Allograft inflammatory factor-1 (AIF-1) is a 17-kDa-peptide identified in rat cardiac allografts undergoing chronic rejection and in activated microglial cells in inflammatory autoimune disease of the CNS. We have investigated the expression of AIF-1 in 18 autopsy cases of human focal cerebral infarction. AIF-1-positive cells show the morphology of microglia and are CD68- but not GFAP-positive. The peptide is expressed at a low level in normal brain. In infarctions, activated microglial cells in the area of glial reaction show strongly enhanced cytoplasmic immunoreactivity. The density of AIF-1-expressing cells increases during the first three days post infarction and remains elevated until chronic cystic stages. The upregulation of AIF-1-immunoreactivity precedes the rise in expression of the S-100-protein MRP-8. We conclude that AIF-1 is a sensitive marker of human microglial activation not only in inflammation but also in non-inflammatory lesions of the CNS.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
AIF1Humanbrain infarction  IEP protein:increased expression:brain white matter (human)RGD 
Aif1Ratbrain infarction  ISOAIF1 (Homo sapiens)protein:increased expression:brain white matter (human)RGD 
Aif1Mousebrain infarction  ISOAIF1 (Homo sapiens)protein:increased expression:brain white matter (human)RGD 


Genes (Rattus norvegicus)
Aif1  (allograft inflammatory factor 1)

Genes (Mus musculus)
Aif1  (allograft inflammatory factor 1)

Genes (Homo sapiens)
AIF1  (allograft inflammatory factor 1)